Preoperative elevation of serum C-reactive protein as an independent prognostic indicator of colorectal carcinoma

Tadahiro Nozoe, Emiko Mori, Ikuo Takahashi, Takahiro Ezaki

研究成果: ジャーナルへの寄稿記事

35 引用 (Scopus)

抄録

Purpose. The preoperative elevation of serum C-reactive protein (CRP) is thought to be a prognosticator of carcinomas of the digestive tract. We conducted this study to investigate the clinical importance of the preoperative elevation of serum CRP in patients with colorectal carcinoma (CRC). Methods. We investigated the correlation between an elevated preoperative serum CRP level and the clinicopathologic factors, including prognosis, of 116 patients who underwent resection of CRC. Results. Forty-seven (40.5%) patients had an elevated serum CRP value preoperatively (group H) and 69 (59.5%) did not (group L). There were significant differences in the tumor size, proportion of poorly differentiated tumors, depth of invasion, lymph node metastasis, lymphatic invasion, and tumor stage between the two groups. Survival was significantly lower in group H than in group L (P < 0.0001). Multivariate analysis showed that the preoperative elevation of serum CRP (P = 0.0007), as well as poor differentiation (P = 0.027) and advanced tumor stage (P = 0.007) were independent prognostic factors in patients with CRC. Conclusion. We found the preoperative elevation of serum CRP to be an independent prognostic indicator of CRC.

元の言語英語
ページ(範囲)597-602
ページ数6
ジャーナルSurgery today
38
発行部数7
DOI
出版物ステータス出版済み - 7 1 2008

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C-Reactive Protein
Blood Proteins
Colorectal Neoplasms
Neoplasms
Lymphatic Metastasis
Gastrointestinal Tract
Multivariate Analysis
Lymph Nodes
Carcinoma
Survival

All Science Journal Classification (ASJC) codes

  • Surgery

これを引用

Preoperative elevation of serum C-reactive protein as an independent prognostic indicator of colorectal carcinoma. / Nozoe, Tadahiro; Mori, Emiko; Takahashi, Ikuo; Ezaki, Takahiro.

:: Surgery today, 巻 38, 番号 7, 01.07.2008, p. 597-602.

研究成果: ジャーナルへの寄稿記事

Nozoe, Tadahiro ; Mori, Emiko ; Takahashi, Ikuo ; Ezaki, Takahiro. / Preoperative elevation of serum C-reactive protein as an independent prognostic indicator of colorectal carcinoma. :: Surgery today. 2008 ; 巻 38, 番号 7. pp. 597-602.
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abstract = "Purpose. The preoperative elevation of serum C-reactive protein (CRP) is thought to be a prognosticator of carcinomas of the digestive tract. We conducted this study to investigate the clinical importance of the preoperative elevation of serum CRP in patients with colorectal carcinoma (CRC). Methods. We investigated the correlation between an elevated preoperative serum CRP level and the clinicopathologic factors, including prognosis, of 116 patients who underwent resection of CRC. Results. Forty-seven (40.5{\%}) patients had an elevated serum CRP value preoperatively (group H) and 69 (59.5{\%}) did not (group L). There were significant differences in the tumor size, proportion of poorly differentiated tumors, depth of invasion, lymph node metastasis, lymphatic invasion, and tumor stage between the two groups. Survival was significantly lower in group H than in group L (P < 0.0001). Multivariate analysis showed that the preoperative elevation of serum CRP (P = 0.0007), as well as poor differentiation (P = 0.027) and advanced tumor stage (P = 0.007) were independent prognostic factors in patients with CRC. Conclusion. We found the preoperative elevation of serum CRP to be an independent prognostic indicator of CRC.",
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AU - Mori, Emiko

AU - Takahashi, Ikuo

AU - Ezaki, Takahiro

PY - 2008/7/1

Y1 - 2008/7/1

N2 - Purpose. The preoperative elevation of serum C-reactive protein (CRP) is thought to be a prognosticator of carcinomas of the digestive tract. We conducted this study to investigate the clinical importance of the preoperative elevation of serum CRP in patients with colorectal carcinoma (CRC). Methods. We investigated the correlation between an elevated preoperative serum CRP level and the clinicopathologic factors, including prognosis, of 116 patients who underwent resection of CRC. Results. Forty-seven (40.5%) patients had an elevated serum CRP value preoperatively (group H) and 69 (59.5%) did not (group L). There were significant differences in the tumor size, proportion of poorly differentiated tumors, depth of invasion, lymph node metastasis, lymphatic invasion, and tumor stage between the two groups. Survival was significantly lower in group H than in group L (P < 0.0001). Multivariate analysis showed that the preoperative elevation of serum CRP (P = 0.0007), as well as poor differentiation (P = 0.027) and advanced tumor stage (P = 0.007) were independent prognostic factors in patients with CRC. Conclusion. We found the preoperative elevation of serum CRP to be an independent prognostic indicator of CRC.

AB - Purpose. The preoperative elevation of serum C-reactive protein (CRP) is thought to be a prognosticator of carcinomas of the digestive tract. We conducted this study to investigate the clinical importance of the preoperative elevation of serum CRP in patients with colorectal carcinoma (CRC). Methods. We investigated the correlation between an elevated preoperative serum CRP level and the clinicopathologic factors, including prognosis, of 116 patients who underwent resection of CRC. Results. Forty-seven (40.5%) patients had an elevated serum CRP value preoperatively (group H) and 69 (59.5%) did not (group L). There were significant differences in the tumor size, proportion of poorly differentiated tumors, depth of invasion, lymph node metastasis, lymphatic invasion, and tumor stage between the two groups. Survival was significantly lower in group H than in group L (P < 0.0001). Multivariate analysis showed that the preoperative elevation of serum CRP (P = 0.0007), as well as poor differentiation (P = 0.027) and advanced tumor stage (P = 0.007) were independent prognostic factors in patients with CRC. Conclusion. We found the preoperative elevation of serum CRP to be an independent prognostic indicator of CRC.

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