Preparation and biomedical application of self-organized honeycomb-patterned polymer films

Takahito Kawano, Nagayoshi Iwama, Hiroshi Ishihata, Hidetoshi Shimauchi, Masatsugu Shimomura

研究成果: Chapter in Book/Report/Conference proceedingChapter

4 被引用数 (Scopus)

抄録

We found that self organized honeycomb patterned porous polymer films (honeycomb films) prepared by casting polymer dissolved in a water immiscible solvent under high humidity. We demonstrated that the microtopography of the honeycomb film strongly affected human mesenchymal stem cells (hMSCs) and periodontal ligament (PDL) cells, which were the important cell sources for tissue engineering. hMSCs on the honeycomb films having smallsized (1.5 mm) pores induced a dramatic stem cell spheroid formation. PDL cells on the honeycomb films (pore sizes of 10 mm) formed increasingly elongated cell shape to trap in their pores. The honeycomb films, which controlled cellular morphology by changing only the geometric cues without the inducing media, can be applied as functional biomaterials for the regenerative therapy.

本文言語英語
ホスト出版物のタイトルInterface Oral Health Science 2011
出版社Springer Japan
ページ22-26
ページ数5
ISBN(電子版)9784431540700
ISBN(印刷版)9784431540694
DOI
出版ステータス出版済み - 1 1 2012
外部発表はい

All Science Journal Classification (ASJC) codes

  • Dentistry(all)

フィンガープリント 「Preparation and biomedical application of self-organized honeycomb-patterned polymer films」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル