Preparation of enantioenriched chiral organic molecules by dynamic asymmetric induction from a outer chiral source

Kazunobu Igawa, Yuuya Kawasaki, Yusuke Ano, Takeru Kashiwagi, Kouhei Ogawa, Jun Ichi Hayashi, Ryota Morita, Yukari Yoshioka, Kazuhiro Uehara, Katsuhiko Tomooka

研究成果: ジャーナルへの寄稿評論記事

抄録

To obtain enantioenriched chiral organic molecules, numerous optical resolution and asymmetric synthetic methods have been developed to date. Herein, we introduce a new approach termed dynamic asymmetric induction (DYASIN) for the preparation of enantioenriched chiral molecules based on the stereocontrol of dynamic chiral molecules (DYCMs) using an outer chiral source (OCS). DYASIN makes it possible to obtain the enantioenriched form of dynamic chiral molecules from their racemic form without bond cleavage or bond formation. The thus-obtained enantioenriched molecules can be readily converted into a variety of chiral molecules with stable stereochemistries, without any loss of enantiomeric purity.

元の言語英語
ページ(範囲)726-729
ページ数4
ジャーナルChemistry Letters
48
発行部数7
DOI
出版物ステータス出版済み - 1 1 2019

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Molecules
Stereochemistry

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

これを引用

Preparation of enantioenriched chiral organic molecules by dynamic asymmetric induction from a outer chiral source. / Igawa, Kazunobu; Kawasaki, Yuuya; Ano, Yusuke; Kashiwagi, Takeru; Ogawa, Kouhei; Hayashi, Jun Ichi; Morita, Ryota; Yoshioka, Yukari; Uehara, Kazuhiro; Tomooka, Katsuhiko.

:: Chemistry Letters, 巻 48, 番号 7, 01.01.2019, p. 726-729.

研究成果: ジャーナルへの寄稿評論記事

Igawa, K, Kawasaki, Y, Ano, Y, Kashiwagi, T, Ogawa, K, Hayashi, JI, Morita, R, Yoshioka, Y, Uehara, K & Tomooka, K 2019, 'Preparation of enantioenriched chiral organic molecules by dynamic asymmetric induction from a outer chiral source', Chemistry Letters, 巻. 48, 番号 7, pp. 726-729. https://doi.org/10.1246/cl.190170
Igawa, Kazunobu ; Kawasaki, Yuuya ; Ano, Yusuke ; Kashiwagi, Takeru ; Ogawa, Kouhei ; Hayashi, Jun Ichi ; Morita, Ryota ; Yoshioka, Yukari ; Uehara, Kazuhiro ; Tomooka, Katsuhiko. / Preparation of enantioenriched chiral organic molecules by dynamic asymmetric induction from a outer chiral source. :: Chemistry Letters. 2019 ; 巻 48, 番号 7. pp. 726-729.
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abstract = "To obtain enantioenriched chiral organic molecules, numerous optical resolution and asymmetric synthetic methods have been developed to date. Herein, we introduce a new approach termed dynamic asymmetric induction (DYASIN) for the preparation of enantioenriched chiral molecules based on the stereocontrol of dynamic chiral molecules (DYCMs) using an outer chiral source (OCS). DYASIN makes it possible to obtain the enantioenriched form of dynamic chiral molecules from their racemic form without bond cleavage or bond formation. The thus-obtained enantioenriched molecules can be readily converted into a variety of chiral molecules with stable stereochemistries, without any loss of enantiomeric purity.",
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AU - Igawa, Kazunobu

AU - Kawasaki, Yuuya

AU - Ano, Yusuke

AU - Kashiwagi, Takeru

AU - Ogawa, Kouhei

AU - Hayashi, Jun Ichi

AU - Morita, Ryota

AU - Yoshioka, Yukari

AU - Uehara, Kazuhiro

AU - Tomooka, Katsuhiko

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AB - To obtain enantioenriched chiral organic molecules, numerous optical resolution and asymmetric synthetic methods have been developed to date. Herein, we introduce a new approach termed dynamic asymmetric induction (DYASIN) for the preparation of enantioenriched chiral molecules based on the stereocontrol of dynamic chiral molecules (DYCMs) using an outer chiral source (OCS). DYASIN makes it possible to obtain the enantioenriched form of dynamic chiral molecules from their racemic form without bond cleavage or bond formation. The thus-obtained enantioenriched molecules can be readily converted into a variety of chiral molecules with stable stereochemistries, without any loss of enantiomeric purity.

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