Preparation of glycopolymer-modified gold nanoparticles and a new approach for a lateral flow assay

Jin Ishii, Masayuki Toyoshima, Miyuki Chikae, Yuzuru Takamura, Yoshiko Miura

研究成果: Contribution to journalArticle査読

14 被引用数 (Scopus)

抄録

A novel recognition element has been synthesized using glycopolymer- modified gold nanoparticles (GNPs) in sugar ratios of 0, 6, 12, and 50%. The as-synthesized glycopolymer-modified GNPs have been employed in a novel lateral flow assay for the detection of proteins. A test solution of concanavalin A (ConA) at 0.01-100μgmL-1 was readily detectable with the glycopolymer-modified GNPs with a sugar ratio of 6%. The results were clear enough to be visible with the naked eye, which demonstrates the convenience of this lateral flow assay for performing the detection of Shiga toxins and influenza viruses. Therefore, this lateral flow assay provides an attractive biosensor for the detection of proteins without the handling of toxic reagents, while allowing an easy and rapid procedure

本文言語英語
ページ(範囲)466-470
ページ数5
ジャーナルBulletin of the Chemical Society of Japan
84
5
DOI
出版ステータス出版済み - 5 23 2011

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

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