Preparation of organotitanium molecular layers for biomedical applications

Tomohiko Yoshioka, Kanji Tsuru, Satoshi Hayakawa, Akiyoshi Osaka

研究成果: Contribution to journalArticle査読

4 被引用数 (Scopus)


We prepared an organotitanium molecular layer on stainless-steel (SUS316L) substrates, and evaluated its blood compatibility in terms of blood-clotting time and fibrinogen adsorption properties. Titanium methacrylate triisopropoxide (TMT) was used as the organotitanium molecule. The surface was characterized by contact angle measurement toward distilled water and Fourier transform infrared spectroscopy using a reflection absorption method (FT-IRRAS). The obtained organotitanium molecular layer had little effects on the blood-clotting times such as active partial thromboplastin time (PTT) and prothrombin time (PT). Bovine fibrinogen adsorption on the layer was examined from the absorbance of amide I peak in FT-IRRAS spectra. The organotitanium molecular layer reduced the amount of adsorbed fibrinogen compared with stainless-steel.

ジャーナルMaterials Science and Engineering C
6-8 SPEC. ISS.
出版ステータス出版済み - 12 1 2004

All Science Journal Classification (ASJC) codes

  • 材料科学(全般)
  • 凝縮系物理学
  • 材料力学
  • 機械工学


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