Preparation of osteocompatible Si(IV)-enriched chitosan-silicate hybrids

Yuki Shirosaki, Kanji Tsuru, Hirofumi Moribayashi, Satoshi Hayakawa, Yuri Nakamura, Iain R. Gibson, Akiyoshi Osaka

研究成果: Contribution to journalArticle査読

16 被引用数 (Scopus)

抄録

Chitosan-γ- glycidoxypropyltrimethoxysilane (GPTMS)tetraethoxysilane (TEOS) hybrid membranes were prepared by the solgel method. The effects of Si(IV) released from them on cell proliferation and differentiation were examined in terms of cell metabolic activity and the alkaline phosphatase (ALP) activity of MG63 osteoblastic cells. The amount of Si(IV) released from the hybrid membranes increased with the TEOS content. The released Si(IV) inhibited cell proliferation but promoted cell differentiation. Thus, the osteocompatibility of the chitosan hybrid membranes in the chitosanGPTMSTEOS system can be controlled by the amount of Si(IV) released from them when they are applied to cell culture.

本文言語英語
ページ(範囲)989-992
ページ数4
ジャーナルJournal of the Ceramic Society of Japan
118
1383
DOI
出版ステータス出版済み - 11 2010

All Science Journal Classification (ASJC) codes

  • Ceramics and Composites
  • Chemistry(all)
  • Condensed Matter Physics
  • Materials Chemistry

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