TY - JOUR
T1 - Preparation of osteocompatible Si(IV)-enriched chitosan-silicate hybrids
AU - Shirosaki, Yuki
AU - Tsuru, Kanji
AU - Moribayashi, Hirofumi
AU - Hayakawa, Satoshi
AU - Nakamura, Yuri
AU - Gibson, Iain R.
AU - Osaka, Akiyoshi
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2010/11
Y1 - 2010/11
N2 - Chitosan-γ- glycidoxypropyltrimethoxysilane (GPTMS)tetraethoxysilane (TEOS) hybrid membranes were prepared by the solgel method. The effects of Si(IV) released from them on cell proliferation and differentiation were examined in terms of cell metabolic activity and the alkaline phosphatase (ALP) activity of MG63 osteoblastic cells. The amount of Si(IV) released from the hybrid membranes increased with the TEOS content. The released Si(IV) inhibited cell proliferation but promoted cell differentiation. Thus, the osteocompatibility of the chitosan hybrid membranes in the chitosanGPTMSTEOS system can be controlled by the amount of Si(IV) released from them when they are applied to cell culture.
AB - Chitosan-γ- glycidoxypropyltrimethoxysilane (GPTMS)tetraethoxysilane (TEOS) hybrid membranes were prepared by the solgel method. The effects of Si(IV) released from them on cell proliferation and differentiation were examined in terms of cell metabolic activity and the alkaline phosphatase (ALP) activity of MG63 osteoblastic cells. The amount of Si(IV) released from the hybrid membranes increased with the TEOS content. The released Si(IV) inhibited cell proliferation but promoted cell differentiation. Thus, the osteocompatibility of the chitosan hybrid membranes in the chitosanGPTMSTEOS system can be controlled by the amount of Si(IV) released from them when they are applied to cell culture.
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U2 - 10.2109/jcersj2.118.989
DO - 10.2109/jcersj2.118.989
M3 - Article
AN - SCOPUS:78149287961
SN - 1882-0743
VL - 118
SP - 989
EP - 992
JO - Nippon Seramikkusu Kyokai Gakujutsu Ronbunshi/Journal of the Ceramic Society of Japan
JF - Nippon Seramikkusu Kyokai Gakujutsu Ronbunshi/Journal of the Ceramic Society of Japan
IS - 1383
ER -