Preparation of Sr-containing carbonate apatite as a bone substitute and its properties

Akiko Sakai, Alireza Valanezahad, Masao Ozaki, Kunio Ishikawa, Shigeki Matsuya

研究成果: Contribution to journalArticle査読

6 被引用数 (Scopus)


Sr-containing carbonate apatite (SrCAp) specimens of varied Sr contents, ranging from 0 to 13.3 mol%, were prepared through a phosphate treatment of set gypsum-and-carbonate mixture at 100°C for 7 days. Effects of Sr content in SrCAp on microstructure, osteoblast-like cell (MC3T3-E1) attachment and proliferation, and alkaline phosphatase (ALP) activity were evaluated. Sr 2+ ion substituted Ca 2+ ion in the apatite lattice. Carbonate content was about 9-13.6 wt%, increasing in content level as Sr content increased. Sr addition benefited cell attachment but had no significant influence on cell proliferation, although the latter was inhibited at the highest Sr content. ALP activity reached a peak in specimen containing 3.4 mol% of Sr. The present study revealed that SrCAp is a promising candidate for use as a bone substitute material with good resorbabilty and osteoconductivity.

ジャーナルdental materials journal
出版ステータス出版済み - 2012

All Science Journal Classification (ASJC) codes

  • セラミックおよび複合材料
  • 歯科学(全般)


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