Prescription factors associated with medication non-adherence in Japan assessed from leftover drugs in the SETSUYAKU-BAG campaign

Focus on oral antidiabetic drugs

Kaori Koyanagi, Toshio Kubota, Daisuke Kobayashi, Taro Kihara, Takeo Yoshida, Takamasa Miisho, Tomoko Miura, Yoshiko Sakamoto, Junichi Takaki, Takashi Seo, Takao Shimazoe

研究成果: ジャーナルへの寄稿記事

5 引用 (Scopus)

抄録

Background: Medication adherence has an important influence on health outcomes in patients with chronic diseases. However, few studies have been performed in Japan to determine factors related to medication non-adherence.Objective: The aim of this study was to identify prescription factors related to medication non-adherence by investigating patient characteristics, all prescriptions, and prescriptions for oral antidiabetic drugs (OADs).Methods: A retrospective cross-sectional survey of prescription data about implementation of dosing regimen was performed at community pharmacies engaged in appropriate use of leftover drugs. We evaluated the amount of drugs originally prescribed and the reduced amount after use of leftover drugs, and then calculated prescription reduction ratio (PRR). We analyzed prescription factors contributing to non-adherence based on the PRR.Results: Prescription information for 1207 patients was reviewed, revealing that patients were non-adherent to 58% of prescriptions. Lack of a drug copayment, fewer concurrent drugs, and drugs not in single-dose packaging were associated with non-adherence. Among the 1207 patients, 234 prescriptions for diabetes and 452 OAD formulations were included. Forty-seven percent of prescriptions and 29% of the formulations were non-adherent. A higher dosing frequency and preprandial administration were associated with non-adherence. Among the OADs, adherence was lower for a-glucosidase inhibitors and biguanides than for sulfonylureas.Conclusions: Several factors related to patient characteristics, general drug prescriptions, and OAD prescriptions were associated with non-adherence. Further consideration will be needed to improve adherence to medication in Japan. Health care providers should perform more careful monitoring of adherence in patients with the factors identified by this study.

元の言語英語
記事番号212
ジャーナルFrontiers in Pharmacology
7
発行部数JUL
DOI
出版物ステータス出版済み - 7 20 2016

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Medication Adherence
Hypoglycemic Agents
Prescriptions
Japan
Pharmaceutical Preparations
Drug Prescriptions
Glucosidases
Biguanides
Drug Compounding
Pharmacies
Product Packaging
Patient Compliance
Health Personnel
Chronic Disease
Cross-Sectional Studies

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)

これを引用

Prescription factors associated with medication non-adherence in Japan assessed from leftover drugs in the SETSUYAKU-BAG campaign : Focus on oral antidiabetic drugs. / Koyanagi, Kaori; Kubota, Toshio; Kobayashi, Daisuke; Kihara, Taro; Yoshida, Takeo; Miisho, Takamasa; Miura, Tomoko; Sakamoto, Yoshiko; Takaki, Junichi; Seo, Takashi; Shimazoe, Takao.

:: Frontiers in Pharmacology, 巻 7, 番号 JUL, 212, 20.07.2016.

研究成果: ジャーナルへの寄稿記事

Koyanagi, Kaori ; Kubota, Toshio ; Kobayashi, Daisuke ; Kihara, Taro ; Yoshida, Takeo ; Miisho, Takamasa ; Miura, Tomoko ; Sakamoto, Yoshiko ; Takaki, Junichi ; Seo, Takashi ; Shimazoe, Takao. / Prescription factors associated with medication non-adherence in Japan assessed from leftover drugs in the SETSUYAKU-BAG campaign : Focus on oral antidiabetic drugs. :: Frontiers in Pharmacology. 2016 ; 巻 7, 番号 JUL.
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title = "Prescription factors associated with medication non-adherence in Japan assessed from leftover drugs in the SETSUYAKU-BAG campaign: Focus on oral antidiabetic drugs",
abstract = "Background: Medication adherence has an important influence on health outcomes in patients with chronic diseases. However, few studies have been performed in Japan to determine factors related to medication non-adherence.Objective: The aim of this study was to identify prescription factors related to medication non-adherence by investigating patient characteristics, all prescriptions, and prescriptions for oral antidiabetic drugs (OADs).Methods: A retrospective cross-sectional survey of prescription data about implementation of dosing regimen was performed at community pharmacies engaged in appropriate use of leftover drugs. We evaluated the amount of drugs originally prescribed and the reduced amount after use of leftover drugs, and then calculated prescription reduction ratio (PRR). We analyzed prescription factors contributing to non-adherence based on the PRR.Results: Prescription information for 1207 patients was reviewed, revealing that patients were non-adherent to 58{\%} of prescriptions. Lack of a drug copayment, fewer concurrent drugs, and drugs not in single-dose packaging were associated with non-adherence. Among the 1207 patients, 234 prescriptions for diabetes and 452 OAD formulations were included. Forty-seven percent of prescriptions and 29{\%} of the formulations were non-adherent. A higher dosing frequency and preprandial administration were associated with non-adherence. Among the OADs, adherence was lower for a-glucosidase inhibitors and biguanides than for sulfonylureas.Conclusions: Several factors related to patient characteristics, general drug prescriptions, and OAD prescriptions were associated with non-adherence. Further consideration will be needed to improve adherence to medication in Japan. Health care providers should perform more careful monitoring of adherence in patients with the factors identified by this study.",
author = "Kaori Koyanagi and Toshio Kubota and Daisuke Kobayashi and Taro Kihara and Takeo Yoshida and Takamasa Miisho and Tomoko Miura and Yoshiko Sakamoto and Junichi Takaki and Takashi Seo and Takao Shimazoe",
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T1 - Prescription factors associated with medication non-adherence in Japan assessed from leftover drugs in the SETSUYAKU-BAG campaign

T2 - Focus on oral antidiabetic drugs

AU - Koyanagi, Kaori

AU - Kubota, Toshio

AU - Kobayashi, Daisuke

AU - Kihara, Taro

AU - Yoshida, Takeo

AU - Miisho, Takamasa

AU - Miura, Tomoko

AU - Sakamoto, Yoshiko

AU - Takaki, Junichi

AU - Seo, Takashi

AU - Shimazoe, Takao

PY - 2016/7/20

Y1 - 2016/7/20

N2 - Background: Medication adherence has an important influence on health outcomes in patients with chronic diseases. However, few studies have been performed in Japan to determine factors related to medication non-adherence.Objective: The aim of this study was to identify prescription factors related to medication non-adherence by investigating patient characteristics, all prescriptions, and prescriptions for oral antidiabetic drugs (OADs).Methods: A retrospective cross-sectional survey of prescription data about implementation of dosing regimen was performed at community pharmacies engaged in appropriate use of leftover drugs. We evaluated the amount of drugs originally prescribed and the reduced amount after use of leftover drugs, and then calculated prescription reduction ratio (PRR). We analyzed prescription factors contributing to non-adherence based on the PRR.Results: Prescription information for 1207 patients was reviewed, revealing that patients were non-adherent to 58% of prescriptions. Lack of a drug copayment, fewer concurrent drugs, and drugs not in single-dose packaging were associated with non-adherence. Among the 1207 patients, 234 prescriptions for diabetes and 452 OAD formulations were included. Forty-seven percent of prescriptions and 29% of the formulations were non-adherent. A higher dosing frequency and preprandial administration were associated with non-adherence. Among the OADs, adherence was lower for a-glucosidase inhibitors and biguanides than for sulfonylureas.Conclusions: Several factors related to patient characteristics, general drug prescriptions, and OAD prescriptions were associated with non-adherence. Further consideration will be needed to improve adherence to medication in Japan. Health care providers should perform more careful monitoring of adherence in patients with the factors identified by this study.

AB - Background: Medication adherence has an important influence on health outcomes in patients with chronic diseases. However, few studies have been performed in Japan to determine factors related to medication non-adherence.Objective: The aim of this study was to identify prescription factors related to medication non-adherence by investigating patient characteristics, all prescriptions, and prescriptions for oral antidiabetic drugs (OADs).Methods: A retrospective cross-sectional survey of prescription data about implementation of dosing regimen was performed at community pharmacies engaged in appropriate use of leftover drugs. We evaluated the amount of drugs originally prescribed and the reduced amount after use of leftover drugs, and then calculated prescription reduction ratio (PRR). We analyzed prescription factors contributing to non-adherence based on the PRR.Results: Prescription information for 1207 patients was reviewed, revealing that patients were non-adherent to 58% of prescriptions. Lack of a drug copayment, fewer concurrent drugs, and drugs not in single-dose packaging were associated with non-adherence. Among the 1207 patients, 234 prescriptions for diabetes and 452 OAD formulations were included. Forty-seven percent of prescriptions and 29% of the formulations were non-adherent. A higher dosing frequency and preprandial administration were associated with non-adherence. Among the OADs, adherence was lower for a-glucosidase inhibitors and biguanides than for sulfonylureas.Conclusions: Several factors related to patient characteristics, general drug prescriptions, and OAD prescriptions were associated with non-adherence. Further consideration will be needed to improve adherence to medication in Japan. Health care providers should perform more careful monitoring of adherence in patients with the factors identified by this study.

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U2 - 10.3389/fphar.2016.00212

DO - 10.3389/fphar.2016.00212

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JO - Frontiers in Pharmacology

JF - Frontiers in Pharmacology

SN - 1663-9812

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