Presence of IFN-γ and IL-4 in human periapical granulation tissues and regeneration tissues

Hiroaki Kabashima, Kengo Nagata, Katsumasa Maeda, Tadahiko Iijima

研究成果: Contribution to journalArticle査読

11 被引用数 (Scopus)

抄録

To study mediators associated with the progression of disease and the process of bone regeneration in human apical periodontitis, we examined samples of periapical granulation tissues and regeneration tissues obtained from five patients by use of immunohistochemical methods. Periapical granulation tissues were found to contain a large number of CD4-positive T cells and CD68-positive monocytes/macrophages (CD4: 35.2%, CD68: 32.7%). The CD4-positive T cells and CD68-positive monocytes/macrophages were predominantly present in regeneration tissues (CD4: 62.1%, CD68: 16.0%). In these the percentages of CD4-positive T cells were higher as compared with periapical granulation tissues (from 35.2% to 62.1%). In periapical granulation tissues, CD4-positive T cells stained positively for interferon-γ (IFN-γ) and negatively for interleukin-4 (IL-4). In regeneration tissues, IL-4-producing cells could be detected. However, IFN-γ-producing cells could not be detected. These results suggest that IFN-γ and IL-4 may modulate the pathogenesis of infectious disease and the process of bone regeneration in local inflammation sites such as human apical periodontitis.

本文言語英語
ページ(範囲)289-293
ページ数5
ジャーナルCytokine
14
5
DOI
出版ステータス出版済み - 6 7 2001

All Science Journal Classification (ASJC) codes

  • 免疫アレルギー学
  • 免疫学
  • 生化学
  • 血液学
  • 分子生物学

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