Presence of T-cell receptor mRNA in functionally distinct T cells and elevation during intrathymic differentiation

Yasunobu Yoshikai, Yusuke Yanagi, Nicole Suciu-Foca, Tak W. Mak

    研究成果: ジャーナルへの寄稿記事

    33 引用 (Scopus)

    抄録

    Understanding the differentiation of functionally distinct subsets of T lymphocytes is essential to unravel their crucial role in the immune response and awaits knowledge of the assembly and expression of genes encoding the T-cell receptor. Recently, we have cloned and sequenced complementary DNA that may specify part of the human T-cell receptor1. The deduced protein sequence showed extensive similarity to the entire length of mammalian immunoglobulin light chains1. In addition, sequences corresponding to this message undergo somatic rearrangements2 and are assembled from non-contiguous genomic sequences into a single mRNA molecule3, a mechanism similar to those found in the generation of immunoglobulin messages4. A related molecule from the mouse was also isolated independently by Hedrick et al.5. Here we show that the putative T-cell receptor mRNA is expressed at a relatively high level during intrathymic differentiation before decreasing about 10-20-fold in normal, mature peripheral blood T cells and that it can also be detected in T-cell clones with helper and cytotoxic functions, as well as in at least one clone with suppressor properties.

    元の言語英語
    ページ(範囲)506-508
    ページ数3
    ジャーナルNature
    310
    発行部数5977
    DOI
    出版物ステータス出版済み - 12 1 1984

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    T-Cell Antigen Receptor
    T-Lymphocytes
    Messenger RNA
    Immunoglobulins
    Clone Cells
    T-Cell Receptor Genes
    T-Lymphocyte Subsets
    Blood Cells
    Complementary DNA
    Light
    Proteins

    All Science Journal Classification (ASJC) codes

    • General

    これを引用

    Presence of T-cell receptor mRNA in functionally distinct T cells and elevation during intrathymic differentiation. / Yoshikai, Yasunobu; Yanagi, Yusuke; Suciu-Foca, Nicole; Mak, Tak W.

    :: Nature, 巻 310, 番号 5977, 01.12.1984, p. 506-508.

    研究成果: ジャーナルへの寄稿記事

    Yoshikai, Yasunobu ; Yanagi, Yusuke ; Suciu-Foca, Nicole ; Mak, Tak W. / Presence of T-cell receptor mRNA in functionally distinct T cells and elevation during intrathymic differentiation. :: Nature. 1984 ; 巻 310, 番号 5977. pp. 506-508.
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    abstract = "Understanding the differentiation of functionally distinct subsets of T lymphocytes is essential to unravel their crucial role in the immune response and awaits knowledge of the assembly and expression of genes encoding the T-cell receptor. Recently, we have cloned and sequenced complementary DNA that may specify part of the human T-cell receptor1. The deduced protein sequence showed extensive similarity to the entire length of mammalian immunoglobulin light chains1. In addition, sequences corresponding to this message undergo somatic rearrangements2 and are assembled from non-contiguous genomic sequences into a single mRNA molecule3, a mechanism similar to those found in the generation of immunoglobulin messages4. A related molecule from the mouse was also isolated independently by Hedrick et al.5. Here we show that the putative T-cell receptor mRNA is expressed at a relatively high level during intrathymic differentiation before decreasing about 10-20-fold in normal, mature peripheral blood T cells and that it can also be detected in T-cell clones with helper and cytotoxic functions, as well as in at least one clone with suppressor properties.",
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    N2 - Understanding the differentiation of functionally distinct subsets of T lymphocytes is essential to unravel their crucial role in the immune response and awaits knowledge of the assembly and expression of genes encoding the T-cell receptor. Recently, we have cloned and sequenced complementary DNA that may specify part of the human T-cell receptor1. The deduced protein sequence showed extensive similarity to the entire length of mammalian immunoglobulin light chains1. In addition, sequences corresponding to this message undergo somatic rearrangements2 and are assembled from non-contiguous genomic sequences into a single mRNA molecule3, a mechanism similar to those found in the generation of immunoglobulin messages4. A related molecule from the mouse was also isolated independently by Hedrick et al.5. Here we show that the putative T-cell receptor mRNA is expressed at a relatively high level during intrathymic differentiation before decreasing about 10-20-fold in normal, mature peripheral blood T cells and that it can also be detected in T-cell clones with helper and cytotoxic functions, as well as in at least one clone with suppressor properties.

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