Present and future outlook for dendritic cell (DC)-based vaccine against cancer

Mitsuo Katano, Takashi Morisaki, Mitsunari Nakamura, Kohtaro Matsumoto, Akira Tasaki, Masafumi Nakamura

研究成果: Contribution to journalArticle査読

抄録

We propose that tumors discovered in a clinical setting are already in the world of immune tolerance. In order to induce powerful antitumor immunity, therefore, we will have to develop a new immune surveillance system in the body. We focused on the ongoing noteworthy devices to improve antigen-presenting ability of dendritic cells (DCs) which play a key role in the world of immune surveillance. One approach is to develop strategies capable of prolonging both the activation state and life span of DCs. A second way is to adjust the immunological environment of tumor sites to the immune surveillance world. Finally, we briefly introduce the ongoing trials concerning artificial antigen-presenting systems.

本文言語英語
ページ(範囲)330-338
ページ数9
ジャーナルBiotherapy
19
4
出版ステータス出版済み - 7 2005

All Science Journal Classification (ASJC) codes

  • 腫瘍学
  • 癌研究

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