Preserved gastric motility in patients with early gastric cancer after endoscopic submucosal dissection

Naomi Higuchi, Kazuhiko Nakamura, Eikichi Ihara, Kazuya Akahoshi, Hirotada Akiho, Yorinobu Sumida, Yasuaki Motomura, Masaru Kubokawa, Tetsuhide Ito, Ryoichi Takayanagi

研究成果: ジャーナルへの寄稿記事

6 引用 (Scopus)

抄録

Background and Aim: Endoscopic submucosal dissection (ESD) is now accepted as a minimally invasive treatment for early gastric cancer (EGC). To our knowledge, however, the functional effects of ESD have not been determined in patients with EGC. We therefore investigated whether gastric motility was affected by ESD. Methods: Using the 13C-octanoic acid breath test, gastric emptying of solid test meals was examined in 26 EGC patients and 18 healthy controls, with EGC patients assayed before and about 2 months after ESD. Based on 13CO2 breath-excretion curves, the lag-phase time (Tlag), half-emptying time (T1/2), and gastric emptying coefficient (GEC) were calculated as indices of gastric emptying. Results: In healthy controls, the mean Tlag, T1/2, and GEC were 85.5±4.9min, 148.5±8.0min, and 3.01±0.09h, respectively. Before ESD, the mean Tlag, T1/2, and GEC in the EGC patients were 90.1±5.5min, 174.7±10.4min, 2.64±0.08h, respectively. GEC, but not Tlag or T1/2, differed significantly in the two groups, with gastric emptying slower in EGC patients than in controls. Relative to before ESD, the mean Tlag, T1/2, and GEC in EGC patients after ESD were 109.2%±7.8%, 107.9%±9.6%, 108.4%±4.7%, respectively, indicating that ESD did not significantly affect any of these gastric emptying parameters in EGC patients. Conclusion: ESD is an effective treatment for EGC both in preserving organs and gastric motility.

元の言語英語
ページ(範囲)494-498
ページ数5
ジャーナルJournal of Gastroenterology and Hepatology (Australia)
28
発行部数3
DOI
出版物ステータス出版済み - 1 1 2013

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Gastric Emptying
Stomach Neoplasms
Stomach
Endoscopic Mucosal Resection
Breath Tests
Meals
Therapeutics

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

これを引用

Preserved gastric motility in patients with early gastric cancer after endoscopic submucosal dissection. / Higuchi, Naomi; Nakamura, Kazuhiko; Ihara, Eikichi; Akahoshi, Kazuya; Akiho, Hirotada; Sumida, Yorinobu; Motomura, Yasuaki; Kubokawa, Masaru; Ito, Tetsuhide; Takayanagi, Ryoichi.

:: Journal of Gastroenterology and Hepatology (Australia), 巻 28, 番号 3, 01.01.2013, p. 494-498.

研究成果: ジャーナルへの寄稿記事

Higuchi, N, Nakamura, K, Ihara, E, Akahoshi, K, Akiho, H, Sumida, Y, Motomura, Y, Kubokawa, M, Ito, T & Takayanagi, R 2013, 'Preserved gastric motility in patients with early gastric cancer after endoscopic submucosal dissection', Journal of Gastroenterology and Hepatology (Australia), 巻. 28, 番号 3, pp. 494-498. https://doi.org/10.1111/jgh.12086
Higuchi, Naomi ; Nakamura, Kazuhiko ; Ihara, Eikichi ; Akahoshi, Kazuya ; Akiho, Hirotada ; Sumida, Yorinobu ; Motomura, Yasuaki ; Kubokawa, Masaru ; Ito, Tetsuhide ; Takayanagi, Ryoichi. / Preserved gastric motility in patients with early gastric cancer after endoscopic submucosal dissection. :: Journal of Gastroenterology and Hepatology (Australia). 2013 ; 巻 28, 番号 3. pp. 494-498.
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abstract = "Background and Aim: Endoscopic submucosal dissection (ESD) is now accepted as a minimally invasive treatment for early gastric cancer (EGC). To our knowledge, however, the functional effects of ESD have not been determined in patients with EGC. We therefore investigated whether gastric motility was affected by ESD. Methods: Using the 13C-octanoic acid breath test, gastric emptying of solid test meals was examined in 26 EGC patients and 18 healthy controls, with EGC patients assayed before and about 2 months after ESD. Based on 13CO2 breath-excretion curves, the lag-phase time (Tlag), half-emptying time (T1/2), and gastric emptying coefficient (GEC) were calculated as indices of gastric emptying. Results: In healthy controls, the mean Tlag, T1/2, and GEC were 85.5±4.9min, 148.5±8.0min, and 3.01±0.09h, respectively. Before ESD, the mean Tlag, T1/2, and GEC in the EGC patients were 90.1±5.5min, 174.7±10.4min, 2.64±0.08h, respectively. GEC, but not Tlag or T1/2, differed significantly in the two groups, with gastric emptying slower in EGC patients than in controls. Relative to before ESD, the mean Tlag, T1/2, and GEC in EGC patients after ESD were 109.2{\%}±7.8{\%}, 107.9{\%}±9.6{\%}, 108.4{\%}±4.7{\%}, respectively, indicating that ESD did not significantly affect any of these gastric emptying parameters in EGC patients. Conclusion: ESD is an effective treatment for EGC both in preserving organs and gastric motility.",
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T1 - Preserved gastric motility in patients with early gastric cancer after endoscopic submucosal dissection

AU - Higuchi, Naomi

AU - Nakamura, Kazuhiko

AU - Ihara, Eikichi

AU - Akahoshi, Kazuya

AU - Akiho, Hirotada

AU - Sumida, Yorinobu

AU - Motomura, Yasuaki

AU - Kubokawa, Masaru

AU - Ito, Tetsuhide

AU - Takayanagi, Ryoichi

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Y1 - 2013/1/1

N2 - Background and Aim: Endoscopic submucosal dissection (ESD) is now accepted as a minimally invasive treatment for early gastric cancer (EGC). To our knowledge, however, the functional effects of ESD have not been determined in patients with EGC. We therefore investigated whether gastric motility was affected by ESD. Methods: Using the 13C-octanoic acid breath test, gastric emptying of solid test meals was examined in 26 EGC patients and 18 healthy controls, with EGC patients assayed before and about 2 months after ESD. Based on 13CO2 breath-excretion curves, the lag-phase time (Tlag), half-emptying time (T1/2), and gastric emptying coefficient (GEC) were calculated as indices of gastric emptying. Results: In healthy controls, the mean Tlag, T1/2, and GEC were 85.5±4.9min, 148.5±8.0min, and 3.01±0.09h, respectively. Before ESD, the mean Tlag, T1/2, and GEC in the EGC patients were 90.1±5.5min, 174.7±10.4min, 2.64±0.08h, respectively. GEC, but not Tlag or T1/2, differed significantly in the two groups, with gastric emptying slower in EGC patients than in controls. Relative to before ESD, the mean Tlag, T1/2, and GEC in EGC patients after ESD were 109.2%±7.8%, 107.9%±9.6%, 108.4%±4.7%, respectively, indicating that ESD did not significantly affect any of these gastric emptying parameters in EGC patients. Conclusion: ESD is an effective treatment for EGC both in preserving organs and gastric motility.

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