Prevalence of and risk factors for low bone mineral density in Japanese female patients with systemic lupus erythematosus

Makio Furukawa, Chikako Kiyohara, Hiroshi Tsukamoto, Hiroki Mitoma, Yasutaka Kimoto, Ayumi Uchino, Misato Nakagawa, Kensuke Oryoji, Terufumi Shimoda, Koichi Akashi, Mine Harada, Takahiko Horiuchi

研究成果: ジャーナルへの寄稿記事

9 引用 (Scopus)

抄録

To examine the prevalence of and risk factors for low bone mineral density (BMD) (osteoporosis or osteopenia) in Japanese female patients with systemic lupus erythematosus (SLE). We performed BMD measurements by dual X-ray absorptiometry at the lumbar spine and the hip and collected basic and lifestyle-related, clinical and treatment characteristics among 58 SLE patients. Odds ratios (ORs) and their 95% confidence intervals (CIs) were assessed for associations between low BMD and selected factors among SLE patients. The mean BMD ± SD was 0.90 ± 0.17 g/cm2 at the lumbar spine and 0.76 ± 0.17 g/cm2 at the hip. The prevalence of osteopenia (2.5 SD < T score < 1 SD) was 50.0% and that of osteoporosis (T score < 2.5 SD) was 13.8% in our SLE patients. After adjustment for age and disease duration, we found the number of deliveries (OR = 5.58, 95% CI = 1.31-26.06; P = 0.02) to be a risk factor for overall low BMD (T score < 1 SD) and a maximal dosage of >50 mg/day of oral corticosteroids (OR = 0.25, 95% CI = 0.07-0.91; P = 0.035) as a preventive factor for low BMD at the lumbar spine. Reduced BMD, especially in spinal trabecular bone, was pronounced in Japanese female patients with SLE, particular in those with a history of delivery. A history of high-dose oral corticosteroids was associated with the preservation of BMD at the lumbar spine, however, further study is needed considering the limited sample size.

元の言語英語
ページ(範囲)365-376
ページ数12
ジャーナルRheumatology International
31
発行部数3
DOI
出版物ステータス出版済み - 3 1 2011

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Systemic Lupus Erythematosus
Bone Density
Spine
Metabolic Bone Diseases
Hip
Adrenal Cortex Hormones
Odds Ratio
Confidence Intervals
Photon Absorptiometry
Sample Size
Osteoporosis
Life Style

All Science Journal Classification (ASJC) codes

  • Rheumatology
  • Immunology and Allergy
  • Immunology

これを引用

Prevalence of and risk factors for low bone mineral density in Japanese female patients with systemic lupus erythematosus. / Furukawa, Makio; Kiyohara, Chikako; Tsukamoto, Hiroshi; Mitoma, Hiroki; Kimoto, Yasutaka; Uchino, Ayumi; Nakagawa, Misato; Oryoji, Kensuke; Shimoda, Terufumi; Akashi, Koichi; Harada, Mine; Horiuchi, Takahiko.

:: Rheumatology International, 巻 31, 番号 3, 01.03.2011, p. 365-376.

研究成果: ジャーナルへの寄稿記事

Furukawa, Makio ; Kiyohara, Chikako ; Tsukamoto, Hiroshi ; Mitoma, Hiroki ; Kimoto, Yasutaka ; Uchino, Ayumi ; Nakagawa, Misato ; Oryoji, Kensuke ; Shimoda, Terufumi ; Akashi, Koichi ; Harada, Mine ; Horiuchi, Takahiko. / Prevalence of and risk factors for low bone mineral density in Japanese female patients with systemic lupus erythematosus. :: Rheumatology International. 2011 ; 巻 31, 番号 3. pp. 365-376.
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abstract = "To examine the prevalence of and risk factors for low bone mineral density (BMD) (osteoporosis or osteopenia) in Japanese female patients with systemic lupus erythematosus (SLE). We performed BMD measurements by dual X-ray absorptiometry at the lumbar spine and the hip and collected basic and lifestyle-related, clinical and treatment characteristics among 58 SLE patients. Odds ratios (ORs) and their 95{\%} confidence intervals (CIs) were assessed for associations between low BMD and selected factors among SLE patients. The mean BMD ± SD was 0.90 ± 0.17 g/cm2 at the lumbar spine and 0.76 ± 0.17 g/cm2 at the hip. The prevalence of osteopenia (2.5 SD < T score < 1 SD) was 50.0{\%} and that of osteoporosis (T score < 2.5 SD) was 13.8{\%} in our SLE patients. After adjustment for age and disease duration, we found the number of deliveries (OR = 5.58, 95{\%} CI = 1.31-26.06; P = 0.02) to be a risk factor for overall low BMD (T score < 1 SD) and a maximal dosage of >50 mg/day of oral corticosteroids (OR = 0.25, 95{\%} CI = 0.07-0.91; P = 0.035) as a preventive factor for low BMD at the lumbar spine. Reduced BMD, especially in spinal trabecular bone, was pronounced in Japanese female patients with SLE, particular in those with a history of delivery. A history of high-dose oral corticosteroids was associated with the preservation of BMD at the lumbar spine, however, further study is needed considering the limited sample size.",
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AU - Mitoma, Hiroki

AU - Kimoto, Yasutaka

AU - Uchino, Ayumi

AU - Nakagawa, Misato

AU - Oryoji, Kensuke

AU - Shimoda, Terufumi

AU - Akashi, Koichi

AU - Harada, Mine

AU - Horiuchi, Takahiko

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AB - To examine the prevalence of and risk factors for low bone mineral density (BMD) (osteoporosis or osteopenia) in Japanese female patients with systemic lupus erythematosus (SLE). We performed BMD measurements by dual X-ray absorptiometry at the lumbar spine and the hip and collected basic and lifestyle-related, clinical and treatment characteristics among 58 SLE patients. Odds ratios (ORs) and their 95% confidence intervals (CIs) were assessed for associations between low BMD and selected factors among SLE patients. The mean BMD ± SD was 0.90 ± 0.17 g/cm2 at the lumbar spine and 0.76 ± 0.17 g/cm2 at the hip. The prevalence of osteopenia (2.5 SD < T score < 1 SD) was 50.0% and that of osteoporosis (T score < 2.5 SD) was 13.8% in our SLE patients. After adjustment for age and disease duration, we found the number of deliveries (OR = 5.58, 95% CI = 1.31-26.06; P = 0.02) to be a risk factor for overall low BMD (T score < 1 SD) and a maximal dosage of >50 mg/day of oral corticosteroids (OR = 0.25, 95% CI = 0.07-0.91; P = 0.035) as a preventive factor for low BMD at the lumbar spine. Reduced BMD, especially in spinal trabecular bone, was pronounced in Japanese female patients with SLE, particular in those with a history of delivery. A history of high-dose oral corticosteroids was associated with the preservation of BMD at the lumbar spine, however, further study is needed considering the limited sample size.

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