Prevention of nonspecific adsorption onto a poly(dimethylsiloxane) microchannel in a microsensor chip by using a self-assemble monolayer

Toshikazu Kawaguchi, Hiroyuki Iwasaka, Kiyoshi Matsumoto, Kiyoshi Toko, Norio Miura

研究成果: ジャーナルへの寄稿学術誌査読

1 被引用数 (Scopus)

抄録

Poly (dimethylsiloxane) (PDMS) is meant to be utilized for a miniaturized sensor system. However, protein and biospecies often adsorb onto a PDMS surface nonspecifically. This matter is a serious challenge in the study of miniaturized sensor systems. We provide the solution, which is a prevention technique of nonspecific adsorption onto a PDMS microchip by using a functionalized silane compound selfassembled monolayer. Two demonstrations for bacteria and explosives were examined by atomic force microscopy and x-ray photoelectron spectroscopy. It was found that 1H, 1H, 2H, 2HPerfluorooctyltriethoxysilane self-assembled monolayer on PDMS effectively blocked the nonspecific adsorption of Escherichia coli (O157:H7) and explosives such as 2, 4, 6-trinitrotoluene and 1, 3, 5-trinitroperhydro-1,3,5-triazine (RDX, Research Department Explosive).

本文言語英語
論文番号013012
ジャーナルJournal of Micro/Nanolithography, MEMS, and MOEMS
9
1
DOI
出版ステータス出版済み - 2010

!!!All Science Journal Classification (ASJC) codes

  • 電子材料、光学材料、および磁性材料
  • 原子分子物理学および光学
  • 凝縮系物理学
  • 機械工学
  • 電子工学および電気工学

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