Preventive and therapeutic effects of the selective Rho-kinase inhibitor fasudil on experimental autoimmune neuritis

Arnold Angelo M. Pineda, Motozumi Minohara, Nobutoshi Kawamura, Takuya Matsushita, Ryo Yamasaki, Xiaojia Sun, Hua Piao, Hiroaki Shimokawa, Jun-Ichi Kira

研究成果: ジャーナルへの寄稿記事

14 引用 (Scopus)

抄録

We studied the effects of fasudil, a selective Rho-kinase inhibitor, on experimental autoimmune neuritis (EAN). Continuous parenteral administration of fasudil prevented the development of EAN induced by P0 peptide 180-199 in Lewis rats while it also reduced EAN severity when administered after disease onset. Immunohistochemical examination disclosed a marked decrease in the amount of inflammatory cell infiltration and attenuation of demyelination and axonal degeneration. Specific proliferation of lymphocytes from fasudil-treated rats in response to P0 peptide was significantly reduced as compared with those from phosphate-buffered saline (PBS)-treated rats. Fasudil treatment was associated with a significant reduction in secretion of IFN-γ; by contrast, secretion of IL-4 was almost the same in the fasudil- and PBS-treated groups. As a result, the IFN-γ/IL-4 ratio in the supernatant was significantly deceased in fasudil-treated rats compared with PBS-treated ones. Therefore, our results indicate a beneficial effect of selective blockade of Rho-kinase in animals with autoimmune inflammation of the peripheral nerves, and may provide a rationale for the selective blockade of Rho-kinase as a new therapy for Guillain-Barré syndrome.

元の言語英語
ページ(範囲)115-120
ページ数6
ジャーナルJournal of the Neurological Sciences
306
発行部数1-2
DOI
出版物ステータス出版済み - 7 15 2011

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Experimental Autoimmune Neuritis
rho-Associated Kinases
Therapeutic Uses
Phosphates
Interleukin-4
Peptides
Demyelinating Diseases
Peripheral Nerves
fasudil
Lymphocytes
Inflammation
Therapeutics

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

これを引用

Preventive and therapeutic effects of the selective Rho-kinase inhibitor fasudil on experimental autoimmune neuritis. / Pineda, Arnold Angelo M.; Minohara, Motozumi; Kawamura, Nobutoshi; Matsushita, Takuya; Yamasaki, Ryo; Sun, Xiaojia; Piao, Hua; Shimokawa, Hiroaki; Kira, Jun-Ichi.

:: Journal of the Neurological Sciences, 巻 306, 番号 1-2, 15.07.2011, p. 115-120.

研究成果: ジャーナルへの寄稿記事

Pineda, Arnold Angelo M. ; Minohara, Motozumi ; Kawamura, Nobutoshi ; Matsushita, Takuya ; Yamasaki, Ryo ; Sun, Xiaojia ; Piao, Hua ; Shimokawa, Hiroaki ; Kira, Jun-Ichi. / Preventive and therapeutic effects of the selective Rho-kinase inhibitor fasudil on experimental autoimmune neuritis. :: Journal of the Neurological Sciences. 2011 ; 巻 306, 番号 1-2. pp. 115-120.
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