Primary Retroperitoneal Myxoid Liposarcomas

Nokitaka Setsu, Mototaka Miyake, Susumu Wakai, Fumihiko Nakatani, Eisuke Kobayashi, Hirokazu Chuman, Nobuyoshi Hiraoka, Akira Kawai, Akihiko Yoshida

研究成果: Contribution to journalArticle査読

17 被引用数 (Scopus)

抄録

Myxoid liposarcomas (MLSs) are genetically defined by the presence of DDIT3 gene fusions and most commonly arise in the extremities of young adults. Whether MLSs develop primarily in the retroperitoneum is controversial, and a recent retrospective study found no molecularly confirmed examples. Because MLSs tend to metastasize to deep soft tissues, purported examples of primary retroperitoneal lesions might represent distant metastasis, most commonly from extremities. In addition, well-differentiated or dedifferentiated liposarcomas, which are characterized by MDM2 amplifications, may exhibit prominent myxoid changes and mimic MLSs. Here, we document 5 cases of MLSs that originated in the retroperitoneum that were identified through critical clinicopathologic reevaluation. These cases accounted for 2.3% of 214 primary retroperitoneal liposarcomas and 3.2% of 156 MLSs in our database. They occurred in 3 men and 2 women with a median age of 32 years. All tumors were localized to the retroperitoneum at presentation, and no patient developed extra-abdominal recurrences during the clinical course (median, 50 mo). All 5 cases exhibited at least focal classic histologic findings. All harbored DDIT3 gene rearrangements, and none harbored MDM2 amplifications according to fluorescence in situ hybridization. This study demonstrates that primary MLSs can occur in the retroperitoneum, albeit rarely, and can be accurately diagnosed through combined clinicopathologic and molecular analysis.

本文言語英語
ページ(範囲)1286-1290
ページ数5
ジャーナルAmerican Journal of Surgical Pathology
40
9
DOI
出版ステータス出版済み - 9 1 2016
外部発表はい

All Science Journal Classification (ASJC) codes

  • Anatomy
  • Surgery
  • Pathology and Forensic Medicine

フィンガープリント 「Primary Retroperitoneal Myxoid Liposarcomas」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル