PRMT1 regulates astrocytic differentiation of embryonic neural stem/precursor cells

研究成果: Contribution to journalArticle査読

11 被引用数 (Scopus)

抄録

Arginine methylation is a post-translational modification which is catalyzed by protein arginine methyltransferases (PRMTs). Here, we report that PRMT1 is highly expressed in neural stem/precursor cells (NS/PCs) of mouse embryos, and knockdown of PRMT1 in NS/PCs suppresses the generation of astrocytes. The luciferase assay demonstrated that knockdown of PRMT1 inhibits activation of the promoter of a typical astrocytic marker gene, glial fibrillary acidic protein (Gfap), in NS/PCs. The transcription factor signal transducer and activator of transcription 3 (STAT3) is known to generally be critical for astrocytic differentiation of NS/PCs. We found that PRMT1 methylates arginine residue(s) of STAT3 to regulate its activity positively, resulting in the promotion of astrocytic differentiation of NS/PCs. (Figure presented.).

本文言語英語
ページ(範囲)901-907
ページ数7
ジャーナルJournal of Neurochemistry
142
6
DOI
出版ステータス出版済み - 9 2017

All Science Journal Classification (ASJC) codes

  • 生化学
  • 細胞および分子神経科学

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