PRMT1 regulates astrocytic differentiation of embryonic neural stem/precursor cells

研究成果: ジャーナルへの寄稿記事

2 引用 (Scopus)

抄録

Arginine methylation is a post-translational modification which is catalyzed by protein arginine methyltransferases (PRMTs). Here, we report that PRMT1 is highly expressed in neural stem/precursor cells (NS/PCs) of mouse embryos, and knockdown of PRMT1 in NS/PCs suppresses the generation of astrocytes. The luciferase assay demonstrated that knockdown of PRMT1 inhibits activation of the promoter of a typical astrocytic marker gene, glial fibrillary acidic protein (Gfap), in NS/PCs. The transcription factor signal transducer and activator of transcription 3 (STAT3) is known to generally be critical for astrocytic differentiation of NS/PCs. We found that PRMT1 methylates arginine residue(s) of STAT3 to regulate its activity positively, resulting in the promotion of astrocytic differentiation of NS/PCs. (Figure presented.).

元の言語英語
ページ(範囲)901-907
ページ数7
ジャーナルJournal of Neurochemistry
142
発行部数6
DOI
出版物ステータス出版済み - 9 1 2017

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STAT3 Transcription Factor
Neural Stem Cells
Embryonic Stem Cells
Arginine
Protein-Arginine N-Methyltransferases
Methylation
Glial Fibrillary Acidic Protein
Post Translational Protein Processing
Luciferases
Astrocytes
Assays
Transcription Factors
Embryonic Structures
Genes
Chemical activation
Cells

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Cellular and Molecular Neuroscience

これを引用

PRMT1 regulates astrocytic differentiation of embryonic neural stem/precursor cells. / Honda, Mizuki; Nakashima, Kinichi; Katada, Sayako.

:: Journal of Neurochemistry, 巻 142, 番号 6, 01.09.2017, p. 901-907.

研究成果: ジャーナルへの寄稿記事

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