Pro-/anti-inflammatory cytokine gene polymorphisms and chronic kidney disease: A cross-sectional study

Rieko Okada, Kenji Wakai, Mariko Naito, Emi Morita, Sayo Kawai, Nobuyuki Hamajima, Megumi Hara, Naoyuki Takashima, Sadao Suzuki, Toshiro Takezaki, Keizo Ohnaka, Kokichi Arisawa, Hiroshi Hirohata, Keitaro Matsuo, Haruo Mikami, Michiaki Kubo, Hideo Tanaka

研究成果: ジャーナルへの寄稿記事

20 引用 (Scopus)

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Background. The aim of this study was to explore the associations between common potential functional promoter polymorphisms in pro-/anti-inflammatory cytokine genes and kidney function/chronic kidney disease (CKD) prevalence in a large Japanese population. Methods. A total of 3,323 subjects aged 35-69 were genotyped for all 10 single nucleotide polymorphisms (SNPs) in the promoter regions of candidate genes with minor allele frequencies of > 0.100 in Japanese populations. The estimated glomerular filtration rate (eGFR) and CKD prevalence (eGFR < 60 ml/min/1.73 m2) of the subjects were compared among the genotypes. Results. A higher eGFR and lower prevalence of CKD were observed for the homozygous variants of IL4 -33CC (high IL-4 [anti-inflammatory cytokine]-producing genotype) and IL6 -572GG (low IL-6 [pro-inflammatory cytokine]-producing genotype). Subjects with IL4 CC + IL6 GG showed the highest mean eGFR (79.1 ml/min/1.73 m2) and lowest CKD prevalence (0.0%), while subjects carrying IL4 TT + IL6 CC showed the lowest mean eGFR (73.4 ml/min/1.73 m2) and highest CKD prevalence (17.9%). Conclusions. The functional promoter polymorphisms IL4 T-33C (rs2070874) and IL6 C-572G (rs1800796), which are the only SNPs that affect the IL-4 and IL-6 levels in Japanese subjects, were associated with kidney function and CKD prevalence in a large Japanese population.

元の言語英語
記事番号2
ジャーナルBMC Nephrology
13
発行部数1
DOI
出版物ステータス出版済み - 1 1 2012

    フィンガープリント

All Science Journal Classification (ASJC) codes

  • Nephrology

これを引用

Okada, R., Wakai, K., Naito, M., Morita, E., Kawai, S., Hamajima, N., ... Tanaka, H. (2012). Pro-/anti-inflammatory cytokine gene polymorphisms and chronic kidney disease: A cross-sectional study. BMC Nephrology, 13(1), [2]. https://doi.org/10.1186/1471-2369-13-222230215