Production of In, Au, and Pt nanoparticles by discharge plasmas in water for assessment of their bio-compatibility and toxicity

Takaaki Amano, Thapanut Sarinont, Kazunori Koga, Miyuki Hirata, Akiyo Tanaka, Masaharu Shiratani

研究成果: Contribution to journalArticle査読

抄録

Nanoparticles have great potential for biomedical applications such as early detection, accurate diagnosis, and personalized treatment of cancer. Assessment of bio-compatibility and toxicity of nanoparticles body is an emerging topic for these applications. To study kinetics of nanoparticles in body, we synthesized indium, gold and platinum nanoparticles in aqueous suspension using pulsed electrical discharge plasmas in water. The average size of synthesized primary nanoparticles for indium, gold, and platinum are 6.2 nm, 6.7 nm, and 5.4 nm, whereas the average size of secondary nanoparticles for indium, gold, and platinum are 315 nm, 72.3 nm, and 151 nm, respectively. Synthesized indium nanoparticles are transported from subcutaneous to serum and brain. The indium content in serum for the synthesized nanoparticles is much higher than that for the In2O3 nanoparticles of 150 nm in primary size. For gold and platinum nanoparticles, preliminary examination of intratracheal administration revealed that administration of synthesized nanoparticles with 10 mg/kg BW (body weight) may cause bleedings and/or emphysema in lung.

本文言語英語
ページ(範囲)1301-1306
ページ数6
ジャーナルMRS Advances
1
18
DOI
出版ステータス出版済み - 2016

All Science Journal Classification (ASJC) codes

  • 機械工学
  • 材料力学
  • 材料科学(全般)
  • 凝縮系物理学

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