Prognostic factors associated with mortality in patients with gastric fundal variceal bleeding

Keishi Komori, Masaru Kubokawa, Eikichi Ihara, Kazuya Akahoshi, Kazuhiko Nakamura, Kenta Motomura, Akihide Masumoto

研究成果: ジャーナルへの寄稿記事

4 引用 (Scopus)

抄録

AIM: To determine the prognostic factors associated with mortality in patients with gastric fundal variceal (GFV) bleeding. METHODS: In total, 42 patients were endoscopically diagnosed with GFV bleeding from January 2000 to March 2014. We retrospectively reviewed the patients' medical records and assessed their history, etiology of liver cirrhosis, disease conditions, treatment options for GFV bleeding, medications administered before and after onset of GFV bleeding, blood test results (hemoglobin, albumin, and bilirubin concentrations), and imaging results (including computed tomography and abdominal ultrasonography). We also assessed the prognostic factors associated with short-term mortality (up to 90 d) and long-term mortality in all patients. RESULTS: Multivariate analysis showed that prophylactic administration of antibiotics was an independent prognostic factor associated with decreases in short-term mortality (OR = 0.08, 95%CI: 0.01-0.52) and long-term mortality (OR = 0.27, 95%CI: 0.08-0.91) in patients with GFV bleeding. In contrast, concurrent hepatocellular carcinoma (HCC) and regular use of proton pump inhibitors (PPI) were independent prognostic factors associated with increases in short-term mortality (HCC: OR = 15.4, 95%CI: 2.08-114.75; PPI: OR = 12.76, 95%CI: 2.13-76.52) and long-term mortality (HCC: OR = 7.89, 95%CI: 1.98-31.58; PPI: OR = 10.91, 95%CI: 2.86-41.65) in patients with GFV bleeding. The long-term overall survival rate was significantly lower in patients who regularly used PPI than in those who did not use PPI (P = 0.0074). CONCLUSION: Administration of antibiotics is associated with decreased short- and long-term mortality, while concurrent HCC and regular PPI administration are associated with increased short- and long-term mortality.

元の言語英語
ページ(範囲)496-504
ページ数9
ジャーナルWorld Journal of Gastroenterology
23
発行部数3
DOI
出版物ステータス出版済み - 1 21 2017

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Stomach
Proton Pump Inhibitors
Hemorrhage
Mortality
Hepatocellular Carcinoma
Anti-Bacterial Agents
Hematologic Tests
Bilirubin
Liver Cirrhosis
Medical Records
Liver Diseases
Albumins
Ultrasonography
Hemoglobins
Multivariate Analysis
Survival Rate
History
Tomography

All Science Journal Classification (ASJC) codes

  • Gastroenterology

これを引用

Prognostic factors associated with mortality in patients with gastric fundal variceal bleeding. / Komori, Keishi; Kubokawa, Masaru; Ihara, Eikichi; Akahoshi, Kazuya; Nakamura, Kazuhiko; Motomura, Kenta; Masumoto, Akihide.

:: World Journal of Gastroenterology, 巻 23, 番号 3, 21.01.2017, p. 496-504.

研究成果: ジャーナルへの寄稿記事

Komori, K, Kubokawa, M, Ihara, E, Akahoshi, K, Nakamura, K, Motomura, K & Masumoto, A 2017, 'Prognostic factors associated with mortality in patients with gastric fundal variceal bleeding', World Journal of Gastroenterology, 巻. 23, 番号 3, pp. 496-504. https://doi.org/10.3748/wjg.v23.i3.496
Komori, Keishi ; Kubokawa, Masaru ; Ihara, Eikichi ; Akahoshi, Kazuya ; Nakamura, Kazuhiko ; Motomura, Kenta ; Masumoto, Akihide. / Prognostic factors associated with mortality in patients with gastric fundal variceal bleeding. :: World Journal of Gastroenterology. 2017 ; 巻 23, 番号 3. pp. 496-504.
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title = "Prognostic factors associated with mortality in patients with gastric fundal variceal bleeding",
abstract = "AIM: To determine the prognostic factors associated with mortality in patients with gastric fundal variceal (GFV) bleeding. METHODS: In total, 42 patients were endoscopically diagnosed with GFV bleeding from January 2000 to March 2014. We retrospectively reviewed the patients' medical records and assessed their history, etiology of liver cirrhosis, disease conditions, treatment options for GFV bleeding, medications administered before and after onset of GFV bleeding, blood test results (hemoglobin, albumin, and bilirubin concentrations), and imaging results (including computed tomography and abdominal ultrasonography). We also assessed the prognostic factors associated with short-term mortality (up to 90 d) and long-term mortality in all patients. RESULTS: Multivariate analysis showed that prophylactic administration of antibiotics was an independent prognostic factor associated with decreases in short-term mortality (OR = 0.08, 95{\%}CI: 0.01-0.52) and long-term mortality (OR = 0.27, 95{\%}CI: 0.08-0.91) in patients with GFV bleeding. In contrast, concurrent hepatocellular carcinoma (HCC) and regular use of proton pump inhibitors (PPI) were independent prognostic factors associated with increases in short-term mortality (HCC: OR = 15.4, 95{\%}CI: 2.08-114.75; PPI: OR = 12.76, 95{\%}CI: 2.13-76.52) and long-term mortality (HCC: OR = 7.89, 95{\%}CI: 1.98-31.58; PPI: OR = 10.91, 95{\%}CI: 2.86-41.65) in patients with GFV bleeding. The long-term overall survival rate was significantly lower in patients who regularly used PPI than in those who did not use PPI (P = 0.0074). CONCLUSION: Administration of antibiotics is associated with decreased short- and long-term mortality, while concurrent HCC and regular PPI administration are associated with increased short- and long-term mortality.",
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T1 - Prognostic factors associated with mortality in patients with gastric fundal variceal bleeding

AU - Komori, Keishi

AU - Kubokawa, Masaru

AU - Ihara, Eikichi

AU - Akahoshi, Kazuya

AU - Nakamura, Kazuhiko

AU - Motomura, Kenta

AU - Masumoto, Akihide

PY - 2017/1/21

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N2 - AIM: To determine the prognostic factors associated with mortality in patients with gastric fundal variceal (GFV) bleeding. METHODS: In total, 42 patients were endoscopically diagnosed with GFV bleeding from January 2000 to March 2014. We retrospectively reviewed the patients' medical records and assessed their history, etiology of liver cirrhosis, disease conditions, treatment options for GFV bleeding, medications administered before and after onset of GFV bleeding, blood test results (hemoglobin, albumin, and bilirubin concentrations), and imaging results (including computed tomography and abdominal ultrasonography). We also assessed the prognostic factors associated with short-term mortality (up to 90 d) and long-term mortality in all patients. RESULTS: Multivariate analysis showed that prophylactic administration of antibiotics was an independent prognostic factor associated with decreases in short-term mortality (OR = 0.08, 95%CI: 0.01-0.52) and long-term mortality (OR = 0.27, 95%CI: 0.08-0.91) in patients with GFV bleeding. In contrast, concurrent hepatocellular carcinoma (HCC) and regular use of proton pump inhibitors (PPI) were independent prognostic factors associated with increases in short-term mortality (HCC: OR = 15.4, 95%CI: 2.08-114.75; PPI: OR = 12.76, 95%CI: 2.13-76.52) and long-term mortality (HCC: OR = 7.89, 95%CI: 1.98-31.58; PPI: OR = 10.91, 95%CI: 2.86-41.65) in patients with GFV bleeding. The long-term overall survival rate was significantly lower in patients who regularly used PPI than in those who did not use PPI (P = 0.0074). CONCLUSION: Administration of antibiotics is associated with decreased short- and long-term mortality, while concurrent HCC and regular PPI administration are associated with increased short- and long-term mortality.

AB - AIM: To determine the prognostic factors associated with mortality in patients with gastric fundal variceal (GFV) bleeding. METHODS: In total, 42 patients were endoscopically diagnosed with GFV bleeding from January 2000 to March 2014. We retrospectively reviewed the patients' medical records and assessed their history, etiology of liver cirrhosis, disease conditions, treatment options for GFV bleeding, medications administered before and after onset of GFV bleeding, blood test results (hemoglobin, albumin, and bilirubin concentrations), and imaging results (including computed tomography and abdominal ultrasonography). We also assessed the prognostic factors associated with short-term mortality (up to 90 d) and long-term mortality in all patients. RESULTS: Multivariate analysis showed that prophylactic administration of antibiotics was an independent prognostic factor associated with decreases in short-term mortality (OR = 0.08, 95%CI: 0.01-0.52) and long-term mortality (OR = 0.27, 95%CI: 0.08-0.91) in patients with GFV bleeding. In contrast, concurrent hepatocellular carcinoma (HCC) and regular use of proton pump inhibitors (PPI) were independent prognostic factors associated with increases in short-term mortality (HCC: OR = 15.4, 95%CI: 2.08-114.75; PPI: OR = 12.76, 95%CI: 2.13-76.52) and long-term mortality (HCC: OR = 7.89, 95%CI: 1.98-31.58; PPI: OR = 10.91, 95%CI: 2.86-41.65) in patients with GFV bleeding. The long-term overall survival rate was significantly lower in patients who regularly used PPI than in those who did not use PPI (P = 0.0074). CONCLUSION: Administration of antibiotics is associated with decreased short- and long-term mortality, while concurrent HCC and regular PPI administration are associated with increased short- and long-term mortality.

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