Prognostic factors for survival of herpes simplex virus-associated hemophagocytic lymphohistiocytosis

Motoshi Sonoda, Masataka Ishimura, Katsuhide Eguchi, Akira Shiraishi, Shunsuke Kanno, Noriyuki Kaku, Hirosuke Inoue, Yoshitomo Motomura, Masayuki Ochiai, Yasunari Sakai, Manabu Nakayama, Osamu Ohara, Shouichi Ohga

研究成果: ジャーナルへの寄稿記事

抄録

Hemophagocytic lymphohistiocytosis (HLH) occurs in neonates with disseminated infection of herpes simplex virus (HSV). Little has been reported on the control of rapid HLH progression. We studied the cytokine profile and genetic basis of two index cases with divergent outcomes after early treatment of type 2 HSV infection. One survivor had fever and elevated serum levels of tumor necrosis factor (TNF)-α, interleukin-6 (IL-6), interferon (IFN)-β, and IFN-γ at diagnosis. The other neonate had no fever or TNF-α production, but significant IL-6 or IFN responses during the treatment course, and died 19 days after birth. Among 16 reported cases of neonatal HSV-HLH including index cases, eight deceased neonates experienced significantly less fever at presentation (p = 0.028), lower platelet counts (p = 0.019), and lower ratios of soluble IL-2 receptor (sIL-2R) to ferritin levels (p = 0.044) than eight survivors. The 100-day overall survival rates were significantly higher in patients with fever (p = 0.004), > 100 × 109/L of platelet counts (p = 0.035) or > 20 of sIL-2R/ferritin ratio at diagnosis (p = 0.004). The first febrile and cytokine responses to HSV infection predict the early outcome of neonatal HSV-HLH.

元の言語英語
ページ(範囲)131-136
ページ数6
ジャーナルInternational journal of hematology
111
発行部数1
DOI
出版物ステータス出版済み - 1 1 2020

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Hemophagocytic Lymphohistiocytosis
Simplexvirus
Fever
Survival
Interferons
Interleukin-2 Receptors
Newborn Infant
Virus Diseases
Ferritins
Platelet Count
Survivors
Interleukin-6
Tumor Necrosis Factor-alpha
Cytokines
Herpes Simplex
Survival Rate
Parturition
Therapeutics
Infection
Serum

All Science Journal Classification (ASJC) codes

  • Hematology

これを引用

Prognostic factors for survival of herpes simplex virus-associated hemophagocytic lymphohistiocytosis. / Sonoda, Motoshi; Ishimura, Masataka; Eguchi, Katsuhide; Shiraishi, Akira; Kanno, Shunsuke; Kaku, Noriyuki; Inoue, Hirosuke; Motomura, Yoshitomo; Ochiai, Masayuki; Sakai, Yasunari; Nakayama, Manabu; Ohara, Osamu; Ohga, Shouichi.

:: International journal of hematology, 巻 111, 番号 1, 01.01.2020, p. 131-136.

研究成果: ジャーナルへの寄稿記事

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abstract = "Hemophagocytic lymphohistiocytosis (HLH) occurs in neonates with disseminated infection of herpes simplex virus (HSV). Little has been reported on the control of rapid HLH progression. We studied the cytokine profile and genetic basis of two index cases with divergent outcomes after early treatment of type 2 HSV infection. One survivor had fever and elevated serum levels of tumor necrosis factor (TNF)-α, interleukin-6 (IL-6), interferon (IFN)-β, and IFN-γ at diagnosis. The other neonate had no fever or TNF-α production, but significant IL-6 or IFN responses during the treatment course, and died 19 days after birth. Among 16 reported cases of neonatal HSV-HLH including index cases, eight deceased neonates experienced significantly less fever at presentation (p = 0.028), lower platelet counts (p = 0.019), and lower ratios of soluble IL-2 receptor (sIL-2R) to ferritin levels (p = 0.044) than eight survivors. The 100-day overall survival rates were significantly higher in patients with fever (p = 0.004), > 100 × 109/L of platelet counts (p = 0.035) or > 20 of sIL-2R/ferritin ratio at diagnosis (p = 0.004). The first febrile and cytokine responses to HSV infection predict the early outcome of neonatal HSV-HLH.",
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AU - Sonoda, Motoshi

AU - Ishimura, Masataka

AU - Eguchi, Katsuhide

AU - Shiraishi, Akira

AU - Kanno, Shunsuke

AU - Kaku, Noriyuki

AU - Inoue, Hirosuke

AU - Motomura, Yoshitomo

AU - Ochiai, Masayuki

AU - Sakai, Yasunari

AU - Nakayama, Manabu

AU - Ohara, Osamu

AU - Ohga, Shouichi

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AB - Hemophagocytic lymphohistiocytosis (HLH) occurs in neonates with disseminated infection of herpes simplex virus (HSV). Little has been reported on the control of rapid HLH progression. We studied the cytokine profile and genetic basis of two index cases with divergent outcomes after early treatment of type 2 HSV infection. One survivor had fever and elevated serum levels of tumor necrosis factor (TNF)-α, interleukin-6 (IL-6), interferon (IFN)-β, and IFN-γ at diagnosis. The other neonate had no fever or TNF-α production, but significant IL-6 or IFN responses during the treatment course, and died 19 days after birth. Among 16 reported cases of neonatal HSV-HLH including index cases, eight deceased neonates experienced significantly less fever at presentation (p = 0.028), lower platelet counts (p = 0.019), and lower ratios of soluble IL-2 receptor (sIL-2R) to ferritin levels (p = 0.044) than eight survivors. The 100-day overall survival rates were significantly higher in patients with fever (p = 0.004), > 100 × 109/L of platelet counts (p = 0.035) or > 20 of sIL-2R/ferritin ratio at diagnosis (p = 0.004). The first febrile and cytokine responses to HSV infection predict the early outcome of neonatal HSV-HLH.

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