Prognostic factors of gastroesophageal reflux disease in congenital diaphragmatic hernia: a multicenter study

Keita Terui, Tomoaki Taguchi, Keiji Goishi, Masahiro Hayakawa, Yuko Tazuke, Akiko Yokoi, Hajime Takayasu, Hiroomi Okuyama, Hideo Yoshida, Noriaki Usui

研究成果: Contribution to journalArticle査読

11 被引用数 (Scopus)

抄録

Purpose: Gastroesophageal reflux disease (GERD) is one of the concomitant problems in infants with congenital diaphragmatic hernia (CDH). We assessed risk factors of GERD in CDH patients.Methods: The retrospective observational study for CDH infants was conducted. Cases of CDH who were born between January 2006 and December 2010, were operated in the 9 participating institutions, and survived to discharge were included. Completion of medical therapy for GERD and incidence of surgery were primary outcomes. Kaplan–Meier survival analysis and Cox proportional hazards regression were used.Results: In 182 cases of CDH, the medical therapies for GERD were performed in 23.8 % (40/168), and were completed in 60.0 % (24/40). Prenatal detection of CDH (HR 5.87, CI 1.6–18.8, p = 0.012) and tube feeding at discharge (HR 5.04, 95 % CI 1.3–33.1, p = 0.016) were significantly correlated with unsuccessful weaning from medical therapy. Surgery for GERD was performed in 10.7 % (18/169). Gestational age (HR 4.78, 95 % CI 1.5–21.1, p = 0.006) and diaphragmatic defect of more than 75 % (HR 4.3, 95 % CI 1.6–12.9, p = 0.005) were significantly correlated with need for antireflux surgery.Results: In 182 cases of CDH, the medical therapies for GERD were performed in 23.8 % (40/168), and were completed in 60.0 % (24/40). Prenatal detection of CDH (HR 5.87, CI 1.6–18.8, p = 0.012) and tube feeding at discharge (HR 5.04, 95 % CI 1.3–33.1, p = 0.016) were significantly correlated with unsuccessful weaning from medical therapy. Surgery for GERD was performed in 10.7 % (18/169). Gestational age (HR 4.78, 95 % CI 1.5–21.1, p = 0.006) and diaphragmatic defect of more than 75 % (HR 4.3, 95 % CI 1.6–12.9, p = 0.005) were significantly correlated with need for antireflux surgery.

本文言語英語
ページ(範囲)1129-1134
ページ数6
ジャーナルPediatric surgery international
30
11
DOI
出版ステータス出版済み - 11 2014

All Science Journal Classification (ASJC) codes

  • 小児科学、周産期医学および子どもの健康
  • 外科

フィンガープリント

「Prognostic factors of gastroesophageal reflux disease in congenital diaphragmatic hernia: a multicenter study」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル