TY - JOUR
T1 - Prognostic implication of desmoplastic stroma in synovial sarcoma
T2 - A histological review
AU - Toda, Yu
AU - Yamada, Yuichi
AU - Kohashi, Kenichi
AU - Ishihara, Shin
AU - Ito, Yoshihiro
AU - Susuki, Yosuke
AU - Kawaguchi, Kengo
AU - Kinoshita, Izumi
AU - Kiyozawa, Daisuke
AU - Mori, Taro
AU - Kuboyama, Yusuke
AU - Tateishi, Yuki
AU - Yamamoto, Hidetaka
AU - Fujiwara, Toshifumi
AU - Setsu, Nokitaka
AU - Endo, Makoto
AU - Matsumoto, Yoshihiro
AU - Nakashima, Yasuharu
AU - Mawatari, Masaaki
AU - Oda, Yoshinao
N1 - Publisher Copyright:
© 2021 Elsevier GmbH
PY - 2021/12
Y1 - 2021/12
N2 - Synovial sarcoma (SS) is a malignant soft tissue neoplasm harboring SS18-SSX fusion gene and is histologically characterized by spindle cells and epithelial components. Some investigations have demonstrated that desmoplastic reaction (DR) is an independent prognostic factor of cancers. However, it remains unknown whether DR is of predictive value for the prognosis of synovial sarcoma patients. Here, we reviewed the clinical and histological findings of 88 patients with SS. We defined DR as hyalinized collagenous structures and classified the degree of DR as follows: none, mild, moderate, and severe. Overall, 23 SS cases (24%) showed moderate or severe DR histologically. Statistically, the cases with moderate or severe degree of DR showed poorer prognosis than those with no or mild DR (local recurrence: P = 0.0059, distant metastasis: P = 0.0002, tumor death: P = 0.0382). The findings of the study suggest that the DR of synovial sarcoma could be an important prognostic factor.
AB - Synovial sarcoma (SS) is a malignant soft tissue neoplasm harboring SS18-SSX fusion gene and is histologically characterized by spindle cells and epithelial components. Some investigations have demonstrated that desmoplastic reaction (DR) is an independent prognostic factor of cancers. However, it remains unknown whether DR is of predictive value for the prognosis of synovial sarcoma patients. Here, we reviewed the clinical and histological findings of 88 patients with SS. We defined DR as hyalinized collagenous structures and classified the degree of DR as follows: none, mild, moderate, and severe. Overall, 23 SS cases (24%) showed moderate or severe DR histologically. Statistically, the cases with moderate or severe degree of DR showed poorer prognosis than those with no or mild DR (local recurrence: P = 0.0059, distant metastasis: P = 0.0002, tumor death: P = 0.0382). The findings of the study suggest that the DR of synovial sarcoma could be an important prognostic factor.
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U2 - 10.1016/j.prp.2021.153668
DO - 10.1016/j.prp.2021.153668
M3 - Article
C2 - 34773915
AN - SCOPUS:85118842983
VL - 228
JO - Pathology Research and Practice
JF - Pathology Research and Practice
SN - 0344-0338
M1 - 153668
ER -
