Prognostic significance of a minute amount of ascites during chemoradiotherapy for locally advanced pancreatic cancer

Makoto Shinoto, Katsumasa Nakamura, Yoshiyuki Shioyama, Tomonari Sasaki, Akihiro Nishie, Yoshiki Asayama, Ohga Saiji, Tadamasa Yoshitake, Kotaro Terashima, Kaori Asai, Keiji Matsumoto, Hiroshi Honda

研究成果: ジャーナルへの寄稿記事

抄録

Aim: The aim of this study was to investigate the clinical factors for predicting overall survival (OS) and the significance of a minute amount of ascites on computed tomography (CT) in patients with locally advanced pancreatic cancer (LAPC) treated with chemoradiotherapy (CRT). Patients and Methods: Between 2003 and 2011, 48 consecutive patients with LAPC were treated with CRT. Various clinical factors, including ascites, were evaluated for correlation with OS. A subset analysis of 16 patients with a minute amount of ascites was also performed. Results: The median survival duration and the 1-year OS rates were 11.5 months and 50%, respectively. A minute amount of ascites on CT and elevated carbohydrate antigen 19-9 (CA19-9) level were significantly associated with poorer OS. In 16 patients with ascites, the amount of ascites increased in the course of the disease, and these were considered to be cancerous clinically, regardless of the amount. Conclusion: A minute amount of ascites and CA19-9 were important prognostic factors in CRT. Any amount of ascites was considered an early indicator of peritoneal carcinomatosis in LAPC.

元の言語英語
ページ(範囲)1879-1884
ページ数6
ジャーナルAnticancer research
36
発行部数4
出版物ステータス出版済み - 4 1 2016

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Chemoradiotherapy
Pancreatic Neoplasms
Ascites
Survival
Tomography
Carbohydrates
Antigens
Survival Rate
Carcinoma

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

これを引用

Prognostic significance of a minute amount of ascites during chemoradiotherapy for locally advanced pancreatic cancer. / Shinoto, Makoto; Nakamura, Katsumasa; Shioyama, Yoshiyuki; Sasaki, Tomonari; Nishie, Akihiro; Asayama, Yoshiki; Saiji, Ohga; Yoshitake, Tadamasa; Terashima, Kotaro; Asai, Kaori; Matsumoto, Keiji; Honda, Hiroshi.

:: Anticancer research, 巻 36, 番号 4, 01.04.2016, p. 1879-1884.

研究成果: ジャーナルへの寄稿記事

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abstract = "Aim: The aim of this study was to investigate the clinical factors for predicting overall survival (OS) and the significance of a minute amount of ascites on computed tomography (CT) in patients with locally advanced pancreatic cancer (LAPC) treated with chemoradiotherapy (CRT). Patients and Methods: Between 2003 and 2011, 48 consecutive patients with LAPC were treated with CRT. Various clinical factors, including ascites, were evaluated for correlation with OS. A subset analysis of 16 patients with a minute amount of ascites was also performed. Results: The median survival duration and the 1-year OS rates were 11.5 months and 50{\%}, respectively. A minute amount of ascites on CT and elevated carbohydrate antigen 19-9 (CA19-9) level were significantly associated with poorer OS. In 16 patients with ascites, the amount of ascites increased in the course of the disease, and these were considered to be cancerous clinically, regardless of the amount. Conclusion: A minute amount of ascites and CA19-9 were important prognostic factors in CRT. Any amount of ascites was considered an early indicator of peritoneal carcinomatosis in LAPC.",
author = "Makoto Shinoto and Katsumasa Nakamura and Yoshiyuki Shioyama and Tomonari Sasaki and Akihiro Nishie and Yoshiki Asayama and Ohga Saiji and Tadamasa Yoshitake and Kotaro Terashima and Kaori Asai and Keiji Matsumoto and Hiroshi Honda",
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T1 - Prognostic significance of a minute amount of ascites during chemoradiotherapy for locally advanced pancreatic cancer

AU - Shinoto, Makoto

AU - Nakamura, Katsumasa

AU - Shioyama, Yoshiyuki

AU - Sasaki, Tomonari

AU - Nishie, Akihiro

AU - Asayama, Yoshiki

AU - Saiji, Ohga

AU - Yoshitake, Tadamasa

AU - Terashima, Kotaro

AU - Asai, Kaori

AU - Matsumoto, Keiji

AU - Honda, Hiroshi

PY - 2016/4/1

Y1 - 2016/4/1

N2 - Aim: The aim of this study was to investigate the clinical factors for predicting overall survival (OS) and the significance of a minute amount of ascites on computed tomography (CT) in patients with locally advanced pancreatic cancer (LAPC) treated with chemoradiotherapy (CRT). Patients and Methods: Between 2003 and 2011, 48 consecutive patients with LAPC were treated with CRT. Various clinical factors, including ascites, were evaluated for correlation with OS. A subset analysis of 16 patients with a minute amount of ascites was also performed. Results: The median survival duration and the 1-year OS rates were 11.5 months and 50%, respectively. A minute amount of ascites on CT and elevated carbohydrate antigen 19-9 (CA19-9) level were significantly associated with poorer OS. In 16 patients with ascites, the amount of ascites increased in the course of the disease, and these were considered to be cancerous clinically, regardless of the amount. Conclusion: A minute amount of ascites and CA19-9 were important prognostic factors in CRT. Any amount of ascites was considered an early indicator of peritoneal carcinomatosis in LAPC.

AB - Aim: The aim of this study was to investigate the clinical factors for predicting overall survival (OS) and the significance of a minute amount of ascites on computed tomography (CT) in patients with locally advanced pancreatic cancer (LAPC) treated with chemoradiotherapy (CRT). Patients and Methods: Between 2003 and 2011, 48 consecutive patients with LAPC were treated with CRT. Various clinical factors, including ascites, were evaluated for correlation with OS. A subset analysis of 16 patients with a minute amount of ascites was also performed. Results: The median survival duration and the 1-year OS rates were 11.5 months and 50%, respectively. A minute amount of ascites on CT and elevated carbohydrate antigen 19-9 (CA19-9) level were significantly associated with poorer OS. In 16 patients with ascites, the amount of ascites increased in the course of the disease, and these were considered to be cancerous clinically, regardless of the amount. Conclusion: A minute amount of ascites and CA19-9 were important prognostic factors in CRT. Any amount of ascites was considered an early indicator of peritoneal carcinomatosis in LAPC.

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