Prognostic significance of apoptosis in synovial sarcoma: Correlation with clinicopathologic parameters, cell proliferative activity, and expression of apoptosis-related

Shigeto Kawauchi, Toshiro Fukuda, Yoshinao Oda, Tsuyoshi Saito, Atsunori Oga, Morishige Takeshita, Koichiro Yokoyama, Hirokazu Chuman, Yukihide Iwamoto, Kohsuke Sasaki, Masazumi Tsuneyoshi

研究成果: Contribution to journalArticle査読

41 被引用数 (Scopus)

抄録

bcl-2 overexpression in synovial sarcomas has been recently reported. Although it is widely known that bcl-2 suppresses apoptosis in various cells, there are no studies that have examined the significance of apoptosis in synovial sarcoma. In the present study, we visualized apoptotic tumor cells by the terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate in situ nick end-labeling (TUNEL) method in 49 cases of primary synovial sarcoma. The degree of apoptosis was analyzed in relation to several clinicopathologic parameters, cell proliferative activity, and immunohistochemical expression of apoptosis-related proteins, including bcl- 2, bax, bcl-x, bak, p53, p21 (WAF1/CIP1), Fas, and Fas ligand. TUNEL index (TUNEL-I) significantly correlated with the mitotic index (MI) (n = 0.60, P < .0001) and Ki-67 labeling index (MIB1-I) (n = 0.52, P = 0.0005). There was a highly significant association between high TUNEL-I value (>.8%) and poor prognosis (log-rank test; P < .0001). Many synovial sarcomas were diffusely positive for bcl-2 family proteins (bcl-2, bax, bcl-x, and bak) and were negative or only sporadically positive for Fas, Fas ligand, p53, and p21 (WAF1/CIP1) proteins. The results indicated that increased rate of apoptosis in primary synovial sarcoma was considered to be an indicator of poor prognosis. In addition, apoptosis in synodal sarcoma may be controlled by multiple apoptosis-regulating mechanisms, including the bcl-2 family.

本文言語英語
ページ(範囲)755-765
ページ数11
ジャーナルModern Pathology
13
7
DOI
出版ステータス出版済み - 7 2000

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

フィンガープリント 「Prognostic significance of apoptosis in synovial sarcoma: Correlation with clinicopathologic parameters, cell proliferative activity, and expression of apoptosis-related」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル