Prognostic Significance of Expression of the Epithelial-Mesenchymal Transition-Related Factor Brachyury in Intrathoracic Lymphatic Spread of Non-Small Cell Lung Cancer

Shinichiro Shimamatsu, Tatsuro Okamoto, Akira Haro, Hirokazu Kitahara, Mikihiro Kohno, Yosuke Morodomi, Tetsuzo Tagawa, Shinji Okano, Yoshinao Oda, Yoshihiko Maehara

研究成果: ジャーナルへの寄稿学術誌査読

5 被引用数 (Scopus)

抄録

Background: Brachyury is a transcriptional regulator that plays important roles in epithelial mesenchymal transition (EMT) during development and has been reported to be essential for mesoderm formation in the early human embryo. We investigated Brachyury protein expression in hilar and mediastinal metastatic lymph nodes of non-small cell lung cancer patients and the prognostic significance of Brachyury expression at metastatic sites. Methods: Expression of Brachyury in 115 surgically resected primary lung cancer and corresponding metastatic lymph node samples was evaluated by immunohistochemical staining. The relationships between Brachyury protein expression and the patient’s clinicopathological factors and prognosis were analyzed. Results: Brachyury expression in metastatic lymph nodes was significantly higher than that in the primary tumor (p = 0.012). Patients with high Brachyury expression in the metastatic lymph nodes had significantly poor prognoses (p = 0.0236) compared with patients with low expression. In addition, patients with larger differences in Brachyury expression between metastatic lymph nodes and the primary tumor had significantly poorer prognoses compared with patients with smaller differences (p = 0.0146). The Brachyury protein expression level in metastatic lymph nodes was significantly associated with the protein expression levels of other EMT-related factors (E-cadherin [inverse association], p = 0.0265; Slug, p = 0.029; and interleukin-8, p = 0.0135). Conclusions: High expression of Brachyury protein in metastatic carcinoma cells in the intrathoracic lymph nodes was associated with poor prognosis of lung cancer patients. Increased Brachyury expression during the metastatic process may confer further potential for invasion and metastasis of cancer cells.

本文言語英語
ページ(範囲)1012-1020
ページ数9
ジャーナルAnnals of Surgical Oncology
23
DOI
出版ステータス出版済み - 12月 1 2016

!!!All Science Journal Classification (ASJC) codes

  • 外科
  • 腫瘍学

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