Prognostic significance of postoperative complications after curative resection for patients with esophageal squamous cell carcinoma

Hiroshi Saeki, Satoshi Tsutsumi, Hirotada Tajiri, Takafumi Yukaya, Ryosuke Tsutsumi, Sho Nishimura, Yu Nakaji, Kensuke Kudou, Shingo Akiyama, Yuta Kasagi, Ryota Nakanishi, Yuichiro Nakashima, Masahiko Sugiyama, Kippei Ohgaki, Hideto Sonoda, Eiji Oki, Yoshihiko Maehara

研究成果: ジャーナルへの寄稿記事

26 引用 (Scopus)

抄録

Objective: The objective of this study was to elucidate the impact of postoperative complications on long-term survival after curative resection for esophageal squamous cell carcinoma. Background: The relation between postoperative complications and long-term survival after curative surgery for esophageal squamous cell carcinoma is controversial; thus, this issue should be resolved with a large-scale, well-designed study. Methods: Clinicopathological features and survival of 580 consecutive patients who received curative resection for esophageal squamous cell carcinoma were investigated according to the development of postoperative pulmonary complications and anastomotic leakage. Results: The 5-year survival rates of patients with pStage 0, I, and II disease with postoperative complications (n = 116) were significantly poorer than those of patients without postoperative complications (n = 288) (overall 69.6% vs 46.9%, P < 0.0001; disease-specific; 76.7% vs 58.9%, P < 0.0022), whereas no differences were found in patients with pStage III and IV disease (n = 176). In the univariate and multivariate analyses for disease-specific survival, pT3, pT4, pN positivity, and development of postoperative complications were significant prognostic factors in all patients. Also, when the analysis was limited to the pStage 0, I, and II patients, development of postoperative complications, and pT3, pT4, and pN positivity, were found to be independent poor prognostic factors in multivariate analyses (hazard ratio: 1.56, 95% confidence interval, 1.01-2.41, P = 0.0476). Conclusions: The development of postoperative complications is an independent disease-specific poor prognostic factor after curative resection for patients with less-advanced esophageal squamous cell carcinoma.

元の言語英語
ページ(範囲)527-533
ページ数7
ジャーナルAnnals of surgery
265
発行部数3
DOI
出版物ステータス出版済み - 3 1 2017

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Survival
Multivariate Analysis
Anastomotic Leak
Esophageal Squamous Cell Carcinoma
Survival Rate
Confidence Intervals
Lung

All Science Journal Classification (ASJC) codes

  • Surgery

これを引用

Prognostic significance of postoperative complications after curative resection for patients with esophageal squamous cell carcinoma. / Saeki, Hiroshi; Tsutsumi, Satoshi; Tajiri, Hirotada; Yukaya, Takafumi; Tsutsumi, Ryosuke; Nishimura, Sho; Nakaji, Yu; Kudou, Kensuke; Akiyama, Shingo; Kasagi, Yuta; Nakanishi, Ryota; Nakashima, Yuichiro; Sugiyama, Masahiko; Ohgaki, Kippei; Sonoda, Hideto; Oki, Eiji; Maehara, Yoshihiko.

:: Annals of surgery, 巻 265, 番号 3, 01.03.2017, p. 527-533.

研究成果: ジャーナルへの寄稿記事

Saeki, H, Tsutsumi, S, Tajiri, H, Yukaya, T, Tsutsumi, R, Nishimura, S, Nakaji, Y, Kudou, K, Akiyama, S, Kasagi, Y, Nakanishi, R, Nakashima, Y, Sugiyama, M, Ohgaki, K, Sonoda, H, Oki, E & Maehara, Y 2017, 'Prognostic significance of postoperative complications after curative resection for patients with esophageal squamous cell carcinoma', Annals of surgery, 巻. 265, 番号 3, pp. 527-533. https://doi.org/10.1097/SLA.0000000000001692
Saeki, Hiroshi ; Tsutsumi, Satoshi ; Tajiri, Hirotada ; Yukaya, Takafumi ; Tsutsumi, Ryosuke ; Nishimura, Sho ; Nakaji, Yu ; Kudou, Kensuke ; Akiyama, Shingo ; Kasagi, Yuta ; Nakanishi, Ryota ; Nakashima, Yuichiro ; Sugiyama, Masahiko ; Ohgaki, Kippei ; Sonoda, Hideto ; Oki, Eiji ; Maehara, Yoshihiko. / Prognostic significance of postoperative complications after curative resection for patients with esophageal squamous cell carcinoma. :: Annals of surgery. 2017 ; 巻 265, 番号 3. pp. 527-533.
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abstract = "Objective: The objective of this study was to elucidate the impact of postoperative complications on long-term survival after curative resection for esophageal squamous cell carcinoma. Background: The relation between postoperative complications and long-term survival after curative surgery for esophageal squamous cell carcinoma is controversial; thus, this issue should be resolved with a large-scale, well-designed study. Methods: Clinicopathological features and survival of 580 consecutive patients who received curative resection for esophageal squamous cell carcinoma were investigated according to the development of postoperative pulmonary complications and anastomotic leakage. Results: The 5-year survival rates of patients with pStage 0, I, and II disease with postoperative complications (n = 116) were significantly poorer than those of patients without postoperative complications (n = 288) (overall 69.6{\%} vs 46.9{\%}, P < 0.0001; disease-specific; 76.7{\%} vs 58.9{\%}, P < 0.0022), whereas no differences were found in patients with pStage III and IV disease (n = 176). In the univariate and multivariate analyses for disease-specific survival, pT3, pT4, pN positivity, and development of postoperative complications were significant prognostic factors in all patients. Also, when the analysis was limited to the pStage 0, I, and II patients, development of postoperative complications, and pT3, pT4, and pN positivity, were found to be independent poor prognostic factors in multivariate analyses (hazard ratio: 1.56, 95{\%} confidence interval, 1.01-2.41, P = 0.0476). Conclusions: The development of postoperative complications is an independent disease-specific poor prognostic factor after curative resection for patients with less-advanced esophageal squamous cell carcinoma.",
author = "Hiroshi Saeki and Satoshi Tsutsumi and Hirotada Tajiri and Takafumi Yukaya and Ryosuke Tsutsumi and Sho Nishimura and Yu Nakaji and Kensuke Kudou and Shingo Akiyama and Yuta Kasagi and Ryota Nakanishi and Yuichiro Nakashima and Masahiko Sugiyama and Kippei Ohgaki and Hideto Sonoda and Eiji Oki and Yoshihiko Maehara",
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T1 - Prognostic significance of postoperative complications after curative resection for patients with esophageal squamous cell carcinoma

AU - Saeki, Hiroshi

AU - Tsutsumi, Satoshi

AU - Tajiri, Hirotada

AU - Yukaya, Takafumi

AU - Tsutsumi, Ryosuke

AU - Nishimura, Sho

AU - Nakaji, Yu

AU - Kudou, Kensuke

AU - Akiyama, Shingo

AU - Kasagi, Yuta

AU - Nakanishi, Ryota

AU - Nakashima, Yuichiro

AU - Sugiyama, Masahiko

AU - Ohgaki, Kippei

AU - Sonoda, Hideto

AU - Oki, Eiji

AU - Maehara, Yoshihiko

PY - 2017/3/1

Y1 - 2017/3/1

N2 - Objective: The objective of this study was to elucidate the impact of postoperative complications on long-term survival after curative resection for esophageal squamous cell carcinoma. Background: The relation between postoperative complications and long-term survival after curative surgery for esophageal squamous cell carcinoma is controversial; thus, this issue should be resolved with a large-scale, well-designed study. Methods: Clinicopathological features and survival of 580 consecutive patients who received curative resection for esophageal squamous cell carcinoma were investigated according to the development of postoperative pulmonary complications and anastomotic leakage. Results: The 5-year survival rates of patients with pStage 0, I, and II disease with postoperative complications (n = 116) were significantly poorer than those of patients without postoperative complications (n = 288) (overall 69.6% vs 46.9%, P < 0.0001; disease-specific; 76.7% vs 58.9%, P < 0.0022), whereas no differences were found in patients with pStage III and IV disease (n = 176). In the univariate and multivariate analyses for disease-specific survival, pT3, pT4, pN positivity, and development of postoperative complications were significant prognostic factors in all patients. Also, when the analysis was limited to the pStage 0, I, and II patients, development of postoperative complications, and pT3, pT4, and pN positivity, were found to be independent poor prognostic factors in multivariate analyses (hazard ratio: 1.56, 95% confidence interval, 1.01-2.41, P = 0.0476). Conclusions: The development of postoperative complications is an independent disease-specific poor prognostic factor after curative resection for patients with less-advanced esophageal squamous cell carcinoma.

AB - Objective: The objective of this study was to elucidate the impact of postoperative complications on long-term survival after curative resection for esophageal squamous cell carcinoma. Background: The relation between postoperative complications and long-term survival after curative surgery for esophageal squamous cell carcinoma is controversial; thus, this issue should be resolved with a large-scale, well-designed study. Methods: Clinicopathological features and survival of 580 consecutive patients who received curative resection for esophageal squamous cell carcinoma were investigated according to the development of postoperative pulmonary complications and anastomotic leakage. Results: The 5-year survival rates of patients with pStage 0, I, and II disease with postoperative complications (n = 116) were significantly poorer than those of patients without postoperative complications (n = 288) (overall 69.6% vs 46.9%, P < 0.0001; disease-specific; 76.7% vs 58.9%, P < 0.0022), whereas no differences were found in patients with pStage III and IV disease (n = 176). In the univariate and multivariate analyses for disease-specific survival, pT3, pT4, pN positivity, and development of postoperative complications were significant prognostic factors in all patients. Also, when the analysis was limited to the pStage 0, I, and II patients, development of postoperative complications, and pT3, pT4, and pN positivity, were found to be independent poor prognostic factors in multivariate analyses (hazard ratio: 1.56, 95% confidence interval, 1.01-2.41, P = 0.0476). Conclusions: The development of postoperative complications is an independent disease-specific poor prognostic factor after curative resection for patients with less-advanced esophageal squamous cell carcinoma.

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