Prognostic Significance of Preoperative Urine Cytology in Low-grade Non-muscle-invasive Bladder Cancer

Keijiro Kiyoshima, Masakazu Akitake, masaki shiota, ario takeuchi, Ryosuke Takahashi, Junichi Inokuchi, Katsunori Tatsugami, Akira Yokomizo, Masatoshi Eto

研究成果: ジャーナルへの寄稿記事

3 引用 (Scopus)

抄録

AIM: To examine the clinical significance of preoperative urine cytology in patients with low-grade bladder cancer.

PATIENTS AND METHODS: We retrospectively investigated the records of 155 patients diagnosed with primary low-grade (Ta) urothelial carcinoma of the bladder between January 2000 and September 2014.

RESULTS: Patients with class III or greater cytology had significantly higher-grade (G2) (p=0.01), larger tumors (≥15 mm, p=0.0009) and significantly shorter recurrence-free survival compared to patients with class II or lower cytology (p<0.0001). However, Cox proportional hazards analysis for recurrence-free survival only identified tumor size (≥15 mm) (hazard ratio=5.97, 95% confidence interval=2.39-17.29; p<0.0001) as a predictor of poor prognosis, although patients with class III or higher preoperative cytology showed a tendency towards frequent intravesical recurrence (hazard ratio=1.98, 95% confidence interval=0.96-4.2; p=0.063).

CONCLUSION: Preoperative urine cytology, in addition to tumor size, might be a useful predictor of intravesical recurrence of bladder cancer.

元の言語英語
ページ(範囲)799-802
ページ数4
ジャーナルAnticancer research
36
発行部数2
出版物ステータス出版済み - 2 1 2016

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Urinary Bladder Neoplasms
Cell Biology
Urine
Recurrence
Confidence Intervals
Neoplasms
Survival
Urinary Bladder
Carcinoma

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

これを引用

Prognostic Significance of Preoperative Urine Cytology in Low-grade Non-muscle-invasive Bladder Cancer. / Kiyoshima, Keijiro; Akitake, Masakazu; shiota, masaki; takeuchi, ario; Takahashi, Ryosuke; Inokuchi, Junichi; Tatsugami, Katsunori; Yokomizo, Akira; Eto, Masatoshi.

:: Anticancer research, 巻 36, 番号 2, 01.02.2016, p. 799-802.

研究成果: ジャーナルへの寄稿記事

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AU - Kiyoshima, Keijiro

AU - Akitake, Masakazu

AU - shiota, masaki

AU - takeuchi, ario

AU - Takahashi, Ryosuke

AU - Inokuchi, Junichi

AU - Tatsugami, Katsunori

AU - Yokomizo, Akira

AU - Eto, Masatoshi

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N2 - AIM: To examine the clinical significance of preoperative urine cytology in patients with low-grade bladder cancer.PATIENTS AND METHODS: We retrospectively investigated the records of 155 patients diagnosed with primary low-grade (Ta) urothelial carcinoma of the bladder between January 2000 and September 2014.RESULTS: Patients with class III or greater cytology had significantly higher-grade (G2) (p=0.01), larger tumors (≥15 mm, p=0.0009) and significantly shorter recurrence-free survival compared to patients with class II or lower cytology (p<0.0001). However, Cox proportional hazards analysis for recurrence-free survival only identified tumor size (≥15 mm) (hazard ratio=5.97, 95% confidence interval=2.39-17.29; p<0.0001) as a predictor of poor prognosis, although patients with class III or higher preoperative cytology showed a tendency towards frequent intravesical recurrence (hazard ratio=1.98, 95% confidence interval=0.96-4.2; p=0.063).CONCLUSION: Preoperative urine cytology, in addition to tumor size, might be a useful predictor of intravesical recurrence of bladder cancer.

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