Prognostic Significance of Sarcopenia in Patients with Esophagogastric Junction Cancer or Upper Gastric Cancer

Kensuke Kudou, Hiroshi Saeki, Yuichiro Nakashima, Keitaro Edahiro, Shotaro Korehisa, Daisuke Taniguchi, Ryosuke Tsutsumi, Sho Nishimura, Yu Nakaji, Shingo Akiyama, Hirotada Tajiri, Ryota Nakanishi, Junji Kurashige, Masahiko Sugiyama, Eiji Oki, Yoshihiko Maehara

研究成果: ジャーナルへの寄稿記事

32 引用 (Scopus)

抄録

Background: The association between sarcopenia and postoperative outcomes for patients with gastrointestinal malignancies remains controversial. This study aimed to assess the impact of sarcopenia on short- and long-term outcomes after surgery for esophagogastric junction cancer (EGJC) or upper gastric cancer (UGC). Methods: The study reviewed 148 patients with EGJC or UGC who underwent surgical resection. The patients were categorized into the sarcopenia group or the non-sarcopenia group according to their skeletal muscle index calculated using abdominal computed tomography images. The study compared clinicopathologic factors, postoperative complications, and prognosis between the two groups. Results: Sarcopenia was present in 19 patients (32.2%) with EGJC and 23 patients (25.8%) with UGC. The 5-year overall survival (OS) and recurrence-free survival (RFS) rates were significantly poorer in the sarcopenia group than in the non-sarcopenia group (OS 85.5 vs 54.8%, P = 0.0010; RFS 78.7 vs 51.7%, P = 0.0054). The development of postoperative complications did not differ significantly between the two groups. Both the uni- and multivariate analyses showed that N stage (P < 0.0001) and sarcopenia (P = 0.0024 and 0.0293, respectively) were independent poor prognostic factors for OS. Conclusions: Sarcopenia was strongly associated with a poor long-term prognosis for patients with EGJC or UGC who underwent surgery. The results suggest that special attention might be needed during the development of treatment strategies for patients with sarcopenia who intend to undergo operations for EGJC and UGC.

元の言語英語
ページ(範囲)1804-1810
ページ数7
ジャーナルAnnals of Surgical Oncology
24
発行部数7
DOI
出版物ステータス出版済み - 7 1 2017

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Sarcopenia
Esophagogastric Junction
Stomach Neoplasms
Neoplasms
Survival
Recurrence
Skeletal Muscle
Multivariate Analysis
Survival Rate
Tomography

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oncology

これを引用

Prognostic Significance of Sarcopenia in Patients with Esophagogastric Junction Cancer or Upper Gastric Cancer. / Kudou, Kensuke; Saeki, Hiroshi; Nakashima, Yuichiro; Edahiro, Keitaro; Korehisa, Shotaro; Taniguchi, Daisuke; Tsutsumi, Ryosuke; Nishimura, Sho; Nakaji, Yu; Akiyama, Shingo; Tajiri, Hirotada; Nakanishi, Ryota; Kurashige, Junji; Sugiyama, Masahiko; Oki, Eiji; Maehara, Yoshihiko.

:: Annals of Surgical Oncology, 巻 24, 番号 7, 01.07.2017, p. 1804-1810.

研究成果: ジャーナルへの寄稿記事

Kudou, K, Saeki, H, Nakashima, Y, Edahiro, K, Korehisa, S, Taniguchi, D, Tsutsumi, R, Nishimura, S, Nakaji, Y, Akiyama, S, Tajiri, H, Nakanishi, R, Kurashige, J, Sugiyama, M, Oki, E & Maehara, Y 2017, 'Prognostic Significance of Sarcopenia in Patients with Esophagogastric Junction Cancer or Upper Gastric Cancer', Annals of Surgical Oncology, 巻. 24, 番号 7, pp. 1804-1810. https://doi.org/10.1245/s10434-017-5811-9
Kudou, Kensuke ; Saeki, Hiroshi ; Nakashima, Yuichiro ; Edahiro, Keitaro ; Korehisa, Shotaro ; Taniguchi, Daisuke ; Tsutsumi, Ryosuke ; Nishimura, Sho ; Nakaji, Yu ; Akiyama, Shingo ; Tajiri, Hirotada ; Nakanishi, Ryota ; Kurashige, Junji ; Sugiyama, Masahiko ; Oki, Eiji ; Maehara, Yoshihiko. / Prognostic Significance of Sarcopenia in Patients with Esophagogastric Junction Cancer or Upper Gastric Cancer. :: Annals of Surgical Oncology. 2017 ; 巻 24, 番号 7. pp. 1804-1810.
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abstract = "Background: The association between sarcopenia and postoperative outcomes for patients with gastrointestinal malignancies remains controversial. This study aimed to assess the impact of sarcopenia on short- and long-term outcomes after surgery for esophagogastric junction cancer (EGJC) or upper gastric cancer (UGC). Methods: The study reviewed 148 patients with EGJC or UGC who underwent surgical resection. The patients were categorized into the sarcopenia group or the non-sarcopenia group according to their skeletal muscle index calculated using abdominal computed tomography images. The study compared clinicopathologic factors, postoperative complications, and prognosis between the two groups. Results: Sarcopenia was present in 19 patients (32.2{\%}) with EGJC and 23 patients (25.8{\%}) with UGC. The 5-year overall survival (OS) and recurrence-free survival (RFS) rates were significantly poorer in the sarcopenia group than in the non-sarcopenia group (OS 85.5 vs 54.8{\%}, P = 0.0010; RFS 78.7 vs 51.7{\%}, P = 0.0054). The development of postoperative complications did not differ significantly between the two groups. Both the uni- and multivariate analyses showed that N stage (P < 0.0001) and sarcopenia (P = 0.0024 and 0.0293, respectively) were independent poor prognostic factors for OS. Conclusions: Sarcopenia was strongly associated with a poor long-term prognosis for patients with EGJC or UGC who underwent surgery. The results suggest that special attention might be needed during the development of treatment strategies for patients with sarcopenia who intend to undergo operations for EGJC and UGC.",
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T1 - Prognostic Significance of Sarcopenia in Patients with Esophagogastric Junction Cancer or Upper Gastric Cancer

AU - Kudou, Kensuke

AU - Saeki, Hiroshi

AU - Nakashima, Yuichiro

AU - Edahiro, Keitaro

AU - Korehisa, Shotaro

AU - Taniguchi, Daisuke

AU - Tsutsumi, Ryosuke

AU - Nishimura, Sho

AU - Nakaji, Yu

AU - Akiyama, Shingo

AU - Tajiri, Hirotada

AU - Nakanishi, Ryota

AU - Kurashige, Junji

AU - Sugiyama, Masahiko

AU - Oki, Eiji

AU - Maehara, Yoshihiko

PY - 2017/7/1

Y1 - 2017/7/1

N2 - Background: The association between sarcopenia and postoperative outcomes for patients with gastrointestinal malignancies remains controversial. This study aimed to assess the impact of sarcopenia on short- and long-term outcomes after surgery for esophagogastric junction cancer (EGJC) or upper gastric cancer (UGC). Methods: The study reviewed 148 patients with EGJC or UGC who underwent surgical resection. The patients were categorized into the sarcopenia group or the non-sarcopenia group according to their skeletal muscle index calculated using abdominal computed tomography images. The study compared clinicopathologic factors, postoperative complications, and prognosis between the two groups. Results: Sarcopenia was present in 19 patients (32.2%) with EGJC and 23 patients (25.8%) with UGC. The 5-year overall survival (OS) and recurrence-free survival (RFS) rates were significantly poorer in the sarcopenia group than in the non-sarcopenia group (OS 85.5 vs 54.8%, P = 0.0010; RFS 78.7 vs 51.7%, P = 0.0054). The development of postoperative complications did not differ significantly between the two groups. Both the uni- and multivariate analyses showed that N stage (P < 0.0001) and sarcopenia (P = 0.0024 and 0.0293, respectively) were independent poor prognostic factors for OS. Conclusions: Sarcopenia was strongly associated with a poor long-term prognosis for patients with EGJC or UGC who underwent surgery. The results suggest that special attention might be needed during the development of treatment strategies for patients with sarcopenia who intend to undergo operations for EGJC and UGC.

AB - Background: The association between sarcopenia and postoperative outcomes for patients with gastrointestinal malignancies remains controversial. This study aimed to assess the impact of sarcopenia on short- and long-term outcomes after surgery for esophagogastric junction cancer (EGJC) or upper gastric cancer (UGC). Methods: The study reviewed 148 patients with EGJC or UGC who underwent surgical resection. The patients were categorized into the sarcopenia group or the non-sarcopenia group according to their skeletal muscle index calculated using abdominal computed tomography images. The study compared clinicopathologic factors, postoperative complications, and prognosis between the two groups. Results: Sarcopenia was present in 19 patients (32.2%) with EGJC and 23 patients (25.8%) with UGC. The 5-year overall survival (OS) and recurrence-free survival (RFS) rates were significantly poorer in the sarcopenia group than in the non-sarcopenia group (OS 85.5 vs 54.8%, P = 0.0010; RFS 78.7 vs 51.7%, P = 0.0054). The development of postoperative complications did not differ significantly between the two groups. Both the uni- and multivariate analyses showed that N stage (P < 0.0001) and sarcopenia (P = 0.0024 and 0.0293, respectively) were independent poor prognostic factors for OS. Conclusions: Sarcopenia was strongly associated with a poor long-term prognosis for patients with EGJC or UGC who underwent surgery. The results suggest that special attention might be needed during the development of treatment strategies for patients with sarcopenia who intend to undergo operations for EGJC and UGC.

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