Prognostic significance of urine N1,N12-diacetylspermine in patients with non-small cell lung cancer

Masato Kato, Hideya Ohnishi, Kotaro Matsumoto, Junichi Motoshita, Nobuko Tsuruta, Kazuyuki Higuchi, Mitsuo Katano

研究成果: ジャーナルへの寄稿記事

4 引用 (Scopus)

抄録

Background: Recently N1,N12-diacetylspermine, a diacetylated polyamine derivative, was recognized as a tumor marker in patients with several kinds of cancers. However, the significance of its levels in urine as a prognostic factor has not been elucidated. In the present study, we examined whether the urine N1,N12-diacetylspermine levels can be used as a prognostic factor in patients with NSCLC. Patients and Methods: Urine samples from 251 patients with NSCLC were collected prior to surgery and the urinary N1,N12-diacetylspermine concentration was measured. Thereafter, all 251 patients underwent curative surgery and the analysis of prognosis was performed for over 10 years. Out of the 251 patients, 91 had recurrent disease. The significance of the urinary N1,N12-diacetylspermine level as a prognostic factor among all 251 patients and among the 91 patients with recurrence was evaluated. Results: Univariate analysis of all 251 patients showed that the level of urinary N1,N12-diacetylspermine was a significant prognostic factor for disease-free survival and overall survival; however, multivariate analysis showed it had no significance. Conversely, the univariate and multivariate analyses of postrecurrent survival of the 91 patients with recurrence showed that urinary N1,N12-diacetylspermine was an independent prognostic factor for post-recurrent survival. Conclusion: Patients with recurrence with positive urinary N1,N12-diacetylspermine should undergo more intensive care and determination of urinary N1,N12-diacetylspermine may contribute to improvement of prognosis of NSCLC.

元の言語英語
ページ(範囲)3053-3060
ページ数8
ジャーナルAnticancer research
34
発行部数6
出版物ステータス出版済み - 1 1 2014

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Non-Small Cell Lung Carcinoma
Urine
Recurrence
Survival
N',N''-diacetylspermine
Multivariate Analysis
Polyamines
Critical Care
Tumor Biomarkers
Disease-Free Survival

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

これを引用

Kato, M., Ohnishi, H., Matsumoto, K., Motoshita, J., Tsuruta, N., Higuchi, K., & Katano, M. (2014). Prognostic significance of urine N1,N12-diacetylspermine in patients with non-small cell lung cancer. Anticancer research, 34(6), 3053-3060.

Prognostic significance of urine N1,N12-diacetylspermine in patients with non-small cell lung cancer. / Kato, Masato; Ohnishi, Hideya; Matsumoto, Kotaro; Motoshita, Junichi; Tsuruta, Nobuko; Higuchi, Kazuyuki; Katano, Mitsuo.

:: Anticancer research, 巻 34, 番号 6, 01.01.2014, p. 3053-3060.

研究成果: ジャーナルへの寄稿記事

Kato, M, Ohnishi, H, Matsumoto, K, Motoshita, J, Tsuruta, N, Higuchi, K & Katano, M 2014, 'Prognostic significance of urine N1,N12-diacetylspermine in patients with non-small cell lung cancer', Anticancer research, 巻. 34, 番号 6, pp. 3053-3060.
Kato M, Ohnishi H, Matsumoto K, Motoshita J, Tsuruta N, Higuchi K その他. Prognostic significance of urine N1,N12-diacetylspermine in patients with non-small cell lung cancer. Anticancer research. 2014 1 1;34(6):3053-3060.
Kato, Masato ; Ohnishi, Hideya ; Matsumoto, Kotaro ; Motoshita, Junichi ; Tsuruta, Nobuko ; Higuchi, Kazuyuki ; Katano, Mitsuo. / Prognostic significance of urine N1,N12-diacetylspermine in patients with non-small cell lung cancer. :: Anticancer research. 2014 ; 巻 34, 番号 6. pp. 3053-3060.
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abstract = "Background: Recently N1,N12-diacetylspermine, a diacetylated polyamine derivative, was recognized as a tumor marker in patients with several kinds of cancers. However, the significance of its levels in urine as a prognostic factor has not been elucidated. In the present study, we examined whether the urine N1,N12-diacetylspermine levels can be used as a prognostic factor in patients with NSCLC. Patients and Methods: Urine samples from 251 patients with NSCLC were collected prior to surgery and the urinary N1,N12-diacetylspermine concentration was measured. Thereafter, all 251 patients underwent curative surgery and the analysis of prognosis was performed for over 10 years. Out of the 251 patients, 91 had recurrent disease. The significance of the urinary N1,N12-diacetylspermine level as a prognostic factor among all 251 patients and among the 91 patients with recurrence was evaluated. Results: Univariate analysis of all 251 patients showed that the level of urinary N1,N12-diacetylspermine was a significant prognostic factor for disease-free survival and overall survival; however, multivariate analysis showed it had no significance. Conversely, the univariate and multivariate analyses of postrecurrent survival of the 91 patients with recurrence showed that urinary N1,N12-diacetylspermine was an independent prognostic factor for post-recurrent survival. Conclusion: Patients with recurrence with positive urinary N1,N12-diacetylspermine should undergo more intensive care and determination of urinary N1,N12-diacetylspermine may contribute to improvement of prognosis of NSCLC.",
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AU - Kato, Masato

AU - Ohnishi, Hideya

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AU - Motoshita, Junichi

AU - Tsuruta, Nobuko

AU - Higuchi, Kazuyuki

AU - Katano, Mitsuo

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N2 - Background: Recently N1,N12-diacetylspermine, a diacetylated polyamine derivative, was recognized as a tumor marker in patients with several kinds of cancers. However, the significance of its levels in urine as a prognostic factor has not been elucidated. In the present study, we examined whether the urine N1,N12-diacetylspermine levels can be used as a prognostic factor in patients with NSCLC. Patients and Methods: Urine samples from 251 patients with NSCLC were collected prior to surgery and the urinary N1,N12-diacetylspermine concentration was measured. Thereafter, all 251 patients underwent curative surgery and the analysis of prognosis was performed for over 10 years. Out of the 251 patients, 91 had recurrent disease. The significance of the urinary N1,N12-diacetylspermine level as a prognostic factor among all 251 patients and among the 91 patients with recurrence was evaluated. Results: Univariate analysis of all 251 patients showed that the level of urinary N1,N12-diacetylspermine was a significant prognostic factor for disease-free survival and overall survival; however, multivariate analysis showed it had no significance. Conversely, the univariate and multivariate analyses of postrecurrent survival of the 91 patients with recurrence showed that urinary N1,N12-diacetylspermine was an independent prognostic factor for post-recurrent survival. Conclusion: Patients with recurrence with positive urinary N1,N12-diacetylspermine should undergo more intensive care and determination of urinary N1,N12-diacetylspermine may contribute to improvement of prognosis of NSCLC.

AB - Background: Recently N1,N12-diacetylspermine, a diacetylated polyamine derivative, was recognized as a tumor marker in patients with several kinds of cancers. However, the significance of its levels in urine as a prognostic factor has not been elucidated. In the present study, we examined whether the urine N1,N12-diacetylspermine levels can be used as a prognostic factor in patients with NSCLC. Patients and Methods: Urine samples from 251 patients with NSCLC were collected prior to surgery and the urinary N1,N12-diacetylspermine concentration was measured. Thereafter, all 251 patients underwent curative surgery and the analysis of prognosis was performed for over 10 years. Out of the 251 patients, 91 had recurrent disease. The significance of the urinary N1,N12-diacetylspermine level as a prognostic factor among all 251 patients and among the 91 patients with recurrence was evaluated. Results: Univariate analysis of all 251 patients showed that the level of urinary N1,N12-diacetylspermine was a significant prognostic factor for disease-free survival and overall survival; however, multivariate analysis showed it had no significance. Conversely, the univariate and multivariate analyses of postrecurrent survival of the 91 patients with recurrence showed that urinary N1,N12-diacetylspermine was an independent prognostic factor for post-recurrent survival. Conclusion: Patients with recurrence with positive urinary N1,N12-diacetylspermine should undergo more intensive care and determination of urinary N1,N12-diacetylspermine may contribute to improvement of prognosis of NSCLC.

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