Prognostic value of chromosomal translocations in small-bowel diffuse large B-cell lymphoma

Koji Ikegami, Shotaro Nakamura, Motohiro Esaki, Shunichi Yanai, Minako Hirahashi, Yoshinao Oda, Morishige Takeshita, Takayuki Matsumoto, Takanari Kitazono

研究成果: ジャーナルへの寄稿記事

1 引用 (Scopus)

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Aims: The objective of this study was to investigate the incidence and clinical significance of lymphoma-associated chromosomal translocations, particularly those involving the immunoglobulin heavy chain gene (IGH) locus, in patients with small-bowel diffuse large B-cell lymphoma (DLBCL). Methods and results: Translocations involving IGH, bcl-6, MYC and bcl-2 were investigated with interphase fluorescence in-situ hybridization on paraffin-embedded tissues in 35 patients with primary small-bowel DLBCL, and the overall survival (OS) and progression-free survival (PFS) rates were evaluated with the Kaplan-Meier method. Translocations involving IGH, bcl-6, MYC and bcl-2 were detected in 23 (70%), 12 (36%), eight (24%) and six (18%) of 33 cases, respectively. The patients with IGH translocations showed less frequent relapse or progression of lymphoma (17%) than those without (60%, P = 0.034). Univariate analyses demonstrated that young age, a low international prognostic index, translocations involving IGH, extra copies of MALT1/bcl-2 and bcl-6 immunoexpression were significantly associated with better OS and PFS. Cox multivariate analysis revealed translocations involving IGH to constitute an independent prognostic factor for better PFS, but not better OS. Conclusions: Translocations involving IGH are frequent in cases of small-bowel DLBCL. These translocations may be predictive of a favourable clinical course.

元の言語英語
ページ(範囲)199-209
ページ数11
ジャーナルHistopathology
68
発行部数2
DOI
出版物ステータス出版済み - 1 1 2016

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Genetic Translocation
Lymphoma, Large B-Cell, Diffuse
Disease-Free Survival
Survival
Lymphoma
Immunoglobulin Heavy Chain Genes
Interphase
Fluorescence In Situ Hybridization
Paraffin
Multivariate Analysis
Survival Rate
Recurrence
Incidence

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Histology

これを引用

Prognostic value of chromosomal translocations in small-bowel diffuse large B-cell lymphoma. / Ikegami, Koji; Nakamura, Shotaro; Esaki, Motohiro; Yanai, Shunichi; Hirahashi, Minako; Oda, Yoshinao; Takeshita, Morishige; Matsumoto, Takayuki; Kitazono, Takanari.

:: Histopathology, 巻 68, 番号 2, 01.01.2016, p. 199-209.

研究成果: ジャーナルへの寄稿記事

Ikegami, K, Nakamura, S, Esaki, M, Yanai, S, Hirahashi, M, Oda, Y, Takeshita, M, Matsumoto, T & Kitazono, T 2016, 'Prognostic value of chromosomal translocations in small-bowel diffuse large B-cell lymphoma', Histopathology, 巻. 68, 番号 2, pp. 199-209. https://doi.org/10.1111/his.12731
Ikegami, Koji ; Nakamura, Shotaro ; Esaki, Motohiro ; Yanai, Shunichi ; Hirahashi, Minako ; Oda, Yoshinao ; Takeshita, Morishige ; Matsumoto, Takayuki ; Kitazono, Takanari. / Prognostic value of chromosomal translocations in small-bowel diffuse large B-cell lymphoma. :: Histopathology. 2016 ; 巻 68, 番号 2. pp. 199-209.
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abstract = "Aims: The objective of this study was to investigate the incidence and clinical significance of lymphoma-associated chromosomal translocations, particularly those involving the immunoglobulin heavy chain gene (IGH) locus, in patients with small-bowel diffuse large B-cell lymphoma (DLBCL). Methods and results: Translocations involving IGH, bcl-6, MYC and bcl-2 were investigated with interphase fluorescence in-situ hybridization on paraffin-embedded tissues in 35 patients with primary small-bowel DLBCL, and the overall survival (OS) and progression-free survival (PFS) rates were evaluated with the Kaplan-Meier method. Translocations involving IGH, bcl-6, MYC and bcl-2 were detected in 23 (70{\%}), 12 (36{\%}), eight (24{\%}) and six (18{\%}) of 33 cases, respectively. The patients with IGH translocations showed less frequent relapse or progression of lymphoma (17{\%}) than those without (60{\%}, P = 0.034). Univariate analyses demonstrated that young age, a low international prognostic index, translocations involving IGH, extra copies of MALT1/bcl-2 and bcl-6 immunoexpression were significantly associated with better OS and PFS. Cox multivariate analysis revealed translocations involving IGH to constitute an independent prognostic factor for better PFS, but not better OS. Conclusions: Translocations involving IGH are frequent in cases of small-bowel DLBCL. These translocations may be predictive of a favourable clinical course.",
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T1 - Prognostic value of chromosomal translocations in small-bowel diffuse large B-cell lymphoma

AU - Ikegami, Koji

AU - Nakamura, Shotaro

AU - Esaki, Motohiro

AU - Yanai, Shunichi

AU - Hirahashi, Minako

AU - Oda, Yoshinao

AU - Takeshita, Morishige

AU - Matsumoto, Takayuki

AU - Kitazono, Takanari

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N2 - Aims: The objective of this study was to investigate the incidence and clinical significance of lymphoma-associated chromosomal translocations, particularly those involving the immunoglobulin heavy chain gene (IGH) locus, in patients with small-bowel diffuse large B-cell lymphoma (DLBCL). Methods and results: Translocations involving IGH, bcl-6, MYC and bcl-2 were investigated with interphase fluorescence in-situ hybridization on paraffin-embedded tissues in 35 patients with primary small-bowel DLBCL, and the overall survival (OS) and progression-free survival (PFS) rates were evaluated with the Kaplan-Meier method. Translocations involving IGH, bcl-6, MYC and bcl-2 were detected in 23 (70%), 12 (36%), eight (24%) and six (18%) of 33 cases, respectively. The patients with IGH translocations showed less frequent relapse or progression of lymphoma (17%) than those without (60%, P = 0.034). Univariate analyses demonstrated that young age, a low international prognostic index, translocations involving IGH, extra copies of MALT1/bcl-2 and bcl-6 immunoexpression were significantly associated with better OS and PFS. Cox multivariate analysis revealed translocations involving IGH to constitute an independent prognostic factor for better PFS, but not better OS. Conclusions: Translocations involving IGH are frequent in cases of small-bowel DLBCL. These translocations may be predictive of a favourable clinical course.

AB - Aims: The objective of this study was to investigate the incidence and clinical significance of lymphoma-associated chromosomal translocations, particularly those involving the immunoglobulin heavy chain gene (IGH) locus, in patients with small-bowel diffuse large B-cell lymphoma (DLBCL). Methods and results: Translocations involving IGH, bcl-6, MYC and bcl-2 were investigated with interphase fluorescence in-situ hybridization on paraffin-embedded tissues in 35 patients with primary small-bowel DLBCL, and the overall survival (OS) and progression-free survival (PFS) rates were evaluated with the Kaplan-Meier method. Translocations involving IGH, bcl-6, MYC and bcl-2 were detected in 23 (70%), 12 (36%), eight (24%) and six (18%) of 33 cases, respectively. The patients with IGH translocations showed less frequent relapse or progression of lymphoma (17%) than those without (60%, P = 0.034). Univariate analyses demonstrated that young age, a low international prognostic index, translocations involving IGH, extra copies of MALT1/bcl-2 and bcl-6 immunoexpression were significantly associated with better OS and PFS. Cox multivariate analysis revealed translocations involving IGH to constitute an independent prognostic factor for better PFS, but not better OS. Conclusions: Translocations involving IGH are frequent in cases of small-bowel DLBCL. These translocations may be predictive of a favourable clinical course.

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