抄録
The crosslinking of FcεRI by IgE and antigen (Ag) on mast cells initiates activation cascades that lead to allergic responses. Although it was thought that IgE binding to FcεRI is a passive "sensitization", recent reports suggest that IgE actively promotes mast cell survival in the absence of Ag. However, it is largely unknown how these distinct responses are delivered through the same receptor, FcεRI, depending on the types of stimli. As an underlying molecular mechanism for the generation of diverse responses through FcεRI, we found that the quantity and the duration of the signal through the FcεRI γ chain (FcRγ) determine different mast cell responses. Furthermore, FcRγ-mediated sustained Erk activation is critical for IgE-induced mast cell survival through autocrine production of IL-3. Transmembrane adaptors LAT and NTAL contribute to the maintenance of prolonged Erk activation through membrane retention of the Ras-activating complex, Grb2-Sos. In this review, the signal regulation for the distinct responses of mast cells through FcεRI are discussed.
| 元の言語 | 英語 |
|---|---|
| ページ（範囲） | 336-340 |
| ページ数 | 5 |
| ジャーナル | Journal of Pharmacological Sciences |
| 巻 | 106 |
| 発行部数 | 3 |
| DOI | |
| 出版物ステータス | 出版済み - 4 8 2008 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Pharmacology
これを引用
Progress in allergy signal research on mast cells : Signal regulation of multiple mast cell responses through FcεRI. / Yamasaki, Shou; Saito, Takashi.
：: Journal of Pharmacological Sciences, 巻 106, 番号 3, 08.04.2008, p. 336-340.研究成果: ジャーナルへの寄稿 › 小調査
}
TY - JOUR
T1 - Progress in allergy signal research on mast cells
T2 - Signal regulation of multiple mast cell responses through FcεRI
AU - Yamasaki, Shou
AU - Saito, Takashi
PY - 2008/4/8
Y1 - 2008/4/8
N2 - The crosslinking of FcεRI by IgE and antigen (Ag) on mast cells initiates activation cascades that lead to allergic responses. Although it was thought that IgE binding to FcεRI is a passive "sensitization", recent reports suggest that IgE actively promotes mast cell survival in the absence of Ag. However, it is largely unknown how these distinct responses are delivered through the same receptor, FcεRI, depending on the types of stimli. As an underlying molecular mechanism for the generation of diverse responses through FcεRI, we found that the quantity and the duration of the signal through the FcεRI γ chain (FcRγ) determine different mast cell responses. Furthermore, FcRγ-mediated sustained Erk activation is critical for IgE-induced mast cell survival through autocrine production of IL-3. Transmembrane adaptors LAT and NTAL contribute to the maintenance of prolonged Erk activation through membrane retention of the Ras-activating complex, Grb2-Sos. In this review, the signal regulation for the distinct responses of mast cells through FcεRI are discussed.
AB - The crosslinking of FcεRI by IgE and antigen (Ag) on mast cells initiates activation cascades that lead to allergic responses. Although it was thought that IgE binding to FcεRI is a passive "sensitization", recent reports suggest that IgE actively promotes mast cell survival in the absence of Ag. However, it is largely unknown how these distinct responses are delivered through the same receptor, FcεRI, depending on the types of stimli. As an underlying molecular mechanism for the generation of diverse responses through FcεRI, we found that the quantity and the duration of the signal through the FcεRI γ chain (FcRγ) determine different mast cell responses. Furthermore, FcRγ-mediated sustained Erk activation is critical for IgE-induced mast cell survival through autocrine production of IL-3. Transmembrane adaptors LAT and NTAL contribute to the maintenance of prolonged Erk activation through membrane retention of the Ras-activating complex, Grb2-Sos. In this review, the signal regulation for the distinct responses of mast cells through FcεRI are discussed.
UR - http://www.scopus.com/inward/record.url?scp=41549159761&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=41549159761&partnerID=8YFLogxK
U2 - 10.1254/jphs.FM0070251
DO - 10.1254/jphs.FM0070251
M3 - Short survey
C2 - 18360089
AN - SCOPUS:41549159761
VL - 106
SP - 336
EP - 340
JO - Journal of Pharmacological Sciences
JF - Journal of Pharmacological Sciences
SN - 1347-8613
IS - 3
ER -