Progress in allergy signal research on mast cells: Signal regulation of multiple mast cell responses through FcεRI

Shou Yamasaki, Takashi Saito

    研究成果: ジャーナルへの寄稿小調査

    14 引用 (Scopus)

    抄録

    The crosslinking of FcεRI by IgE and antigen (Ag) on mast cells initiates activation cascades that lead to allergic responses. Although it was thought that IgE binding to FcεRI is a passive "sensitization", recent reports suggest that IgE actively promotes mast cell survival in the absence of Ag. However, it is largely unknown how these distinct responses are delivered through the same receptor, FcεRI, depending on the types of stimli. As an underlying molecular mechanism for the generation of diverse responses through FcεRI, we found that the quantity and the duration of the signal through the FcεRI γ chain (FcRγ) determine different mast cell responses. Furthermore, FcRγ-mediated sustained Erk activation is critical for IgE-induced mast cell survival through autocrine production of IL-3. Transmembrane adaptors LAT and NTAL contribute to the maintenance of prolonged Erk activation through membrane retention of the Ras-activating complex, Grb2-Sos. In this review, the signal regulation for the distinct responses of mast cells through FcεRI are discussed.

    元の言語英語
    ページ(範囲)336-340
    ページ数5
    ジャーナルJournal of Pharmacological Sciences
    106
    発行部数3
    DOI
    出版物ステータス出版済み - 4 8 2008

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    Mast Cells
    Hypersensitivity
    Immunoglobulin E
    Research
    Cell Survival
    Antigens
    Interleukin-3
    Maintenance
    Membranes

    All Science Journal Classification (ASJC) codes

    • Pharmacology

    これを引用

    Progress in allergy signal research on mast cells : Signal regulation of multiple mast cell responses through FcεRI. / Yamasaki, Shou; Saito, Takashi.

    :: Journal of Pharmacological Sciences, 巻 106, 番号 3, 08.04.2008, p. 336-340.

    研究成果: ジャーナルへの寄稿小調査

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    abstract = "The crosslinking of FcεRI by IgE and antigen (Ag) on mast cells initiates activation cascades that lead to allergic responses. Although it was thought that IgE binding to FcεRI is a passive {"}sensitization{"}, recent reports suggest that IgE actively promotes mast cell survival in the absence of Ag. However, it is largely unknown how these distinct responses are delivered through the same receptor, FcεRI, depending on the types of stimli. As an underlying molecular mechanism for the generation of diverse responses through FcεRI, we found that the quantity and the duration of the signal through the FcεRI γ chain (FcRγ) determine different mast cell responses. Furthermore, FcRγ-mediated sustained Erk activation is critical for IgE-induced mast cell survival through autocrine production of IL-3. Transmembrane adaptors LAT and NTAL contribute to the maintenance of prolonged Erk activation through membrane retention of the Ras-activating complex, Grb2-Sos. In this review, the signal regulation for the distinct responses of mast cells through FcεRI are discussed.",
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