Progress of research in osteoarthritis. Gene expression and its regulatory mechanisms in the degenerative cartilage in osteoarthritis

Ken Okazaki, Yukihide Iwamoto

研究成果: Contribution to journalReview article査読

3 被引用数 (Scopus)

抄録

Spatiotemporal variations of pathological changes were observed in the osteoarthritis joints. Gene expressions vary depending on the zones in the cartilage. For example, the expressions of degradative enzymes such as matrix metalloproteinases were enhanced in the superficial zone whereas the expression of matrix proteins enhanced at the deep zone. Many factors such as mechanical stress, aging, genetic background, inflammation and phenotypic changes of chondrocytes influence the pathogenesis of osteoarthritis, suggesting the involvement of many regulatory mechanisms in the gene expression. However, discoveries of regulatory factors that provide common pathways for the various phenomenon observed in the osteoarthritis cartilage suggest the interaction and co-operation of these important factors to conduct the pathology of degenerative cartilage.

本文言語英語
ページ(範囲)1578-1585
ページ数8
ジャーナルClinical calcium
19
11
出版ステータス出版済み - 11 2009

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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