Progress on the Design and Development of the Continuous-Flow Total Artificial Heart

Mariko Kobayashi, David J. Horvath, Nicole Mielke, Akira Shiose, Barry Kuban, Mark Goodin, Kiyotaka Fukamachi, Leonard A R Golding

研究成果: ジャーナルへの寄稿記事

28 引用 (Scopus)

抄録

Cleveland Clinic's continuous-flow total artificial heart has one motor and one rotating assembly supported by a hydrodynamic bearing. The right hydraulic output is self regulated by passive axial movement of the rotating assembly to balance itself with the left output. The purpose of this article is to present progress in four areas of development: the automatic speed control system, self-regulation to balance right/left inlet pressures and flows, hemolysis testing using calf blood, and coupled electromagnetics (EMAG) and computational fluid dynamics (CFD) analysis. The relationships between functions of motor power and speed, systemic flow, and systemic vascular resistance (SVR) were used for the sensorless speed control algorithm and demonstrated close correlations. Based on those empirical relationships, systemic flow and SVR were calculated in the system module and showed good correlation with measured pump flow and SVR. The automatic system adjusted the pump's speed to obtain the target flow in response to the calculated SVR. Atrial pressure difference (left minus right atrial pressure) was maintained within ±10mmHg for a wide range of SVR/pulmonary vascular resistance ratios, demonstrating a wide margin of self-regulation under fixed-speed mode and 25% sinusoidally modulated speed mode. Hemolysis test results indicated acceptable values (normalized index of hemolysis <0.01mg/dL). The coupled EMAG/CFD model was validated for use in further device development.

元の言語英語
ページ(範囲)705-713
ページ数9
ジャーナルArtificial Organs
36
発行部数8
DOI
出版物ステータス出版済み - 8 1 2012
外部発表Yes

Fingerprint

Artificial heart
Artificial Heart
Vascular Resistance
Hydrodynamics
Speed control
Hemolysis
Computational fluid dynamics
Atrial Pressure
Bearings (structural)
Electromagnetic Phenomena
Pumps
Dynamic analysis
Dynamic models
Blood
Hydraulics
Control systems
Testing
Pressure
Equipment and Supplies

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

これを引用

Kobayashi, M., Horvath, D. J., Mielke, N., Shiose, A., Kuban, B., Goodin, M., ... Golding, L. A. R. (2012). Progress on the Design and Development of the Continuous-Flow Total Artificial Heart. Artificial Organs, 36(8), 705-713. https://doi.org/10.1111/j.1525-1594.2012.01489.x

Progress on the Design and Development of the Continuous-Flow Total Artificial Heart. / Kobayashi, Mariko; Horvath, David J.; Mielke, Nicole; Shiose, Akira; Kuban, Barry; Goodin, Mark; Fukamachi, Kiyotaka; Golding, Leonard A R.

:: Artificial Organs, 巻 36, 番号 8, 01.08.2012, p. 705-713.

研究成果: ジャーナルへの寄稿記事

Kobayashi, M, Horvath, DJ, Mielke, N, Shiose, A, Kuban, B, Goodin, M, Fukamachi, K & Golding, LAR 2012, 'Progress on the Design and Development of the Continuous-Flow Total Artificial Heart', Artificial Organs, 巻. 36, 番号 8, pp. 705-713. https://doi.org/10.1111/j.1525-1594.2012.01489.x
Kobayashi, Mariko ; Horvath, David J. ; Mielke, Nicole ; Shiose, Akira ; Kuban, Barry ; Goodin, Mark ; Fukamachi, Kiyotaka ; Golding, Leonard A R. / Progress on the Design and Development of the Continuous-Flow Total Artificial Heart. :: Artificial Organs. 2012 ; 巻 36, 番号 8. pp. 705-713.
@article{cc6ef1593d54403b8d119c2fbdcc844e,
title = "Progress on the Design and Development of the Continuous-Flow Total Artificial Heart",
abstract = "Cleveland Clinic's continuous-flow total artificial heart has one motor and one rotating assembly supported by a hydrodynamic bearing. The right hydraulic output is self regulated by passive axial movement of the rotating assembly to balance itself with the left output. The purpose of this article is to present progress in four areas of development: the automatic speed control system, self-regulation to balance right/left inlet pressures and flows, hemolysis testing using calf blood, and coupled electromagnetics (EMAG) and computational fluid dynamics (CFD) analysis. The relationships between functions of motor power and speed, systemic flow, and systemic vascular resistance (SVR) were used for the sensorless speed control algorithm and demonstrated close correlations. Based on those empirical relationships, systemic flow and SVR were calculated in the system module and showed good correlation with measured pump flow and SVR. The automatic system adjusted the pump's speed to obtain the target flow in response to the calculated SVR. Atrial pressure difference (left minus right atrial pressure) was maintained within ±10mmHg for a wide range of SVR/pulmonary vascular resistance ratios, demonstrating a wide margin of self-regulation under fixed-speed mode and 25{\%} sinusoidally modulated speed mode. Hemolysis test results indicated acceptable values (normalized index of hemolysis <0.01mg/dL). The coupled EMAG/CFD model was validated for use in further device development.",
author = "Mariko Kobayashi and Horvath, {David J.} and Nicole Mielke and Akira Shiose and Barry Kuban and Mark Goodin and Kiyotaka Fukamachi and Golding, {Leonard A R}",
year = "2012",
month = "8",
day = "1",
doi = "10.1111/j.1525-1594.2012.01489.x",
language = "English",
volume = "36",
pages = "705--713",
journal = "Artificial Organs",
issn = "0160-564X",
publisher = "Wiley-Blackwell",
number = "8",

}

TY - JOUR

T1 - Progress on the Design and Development of the Continuous-Flow Total Artificial Heart

AU - Kobayashi, Mariko

AU - Horvath, David J.

AU - Mielke, Nicole

AU - Shiose, Akira

AU - Kuban, Barry

AU - Goodin, Mark

AU - Fukamachi, Kiyotaka

AU - Golding, Leonard A R

PY - 2012/8/1

Y1 - 2012/8/1

N2 - Cleveland Clinic's continuous-flow total artificial heart has one motor and one rotating assembly supported by a hydrodynamic bearing. The right hydraulic output is self regulated by passive axial movement of the rotating assembly to balance itself with the left output. The purpose of this article is to present progress in four areas of development: the automatic speed control system, self-regulation to balance right/left inlet pressures and flows, hemolysis testing using calf blood, and coupled electromagnetics (EMAG) and computational fluid dynamics (CFD) analysis. The relationships between functions of motor power and speed, systemic flow, and systemic vascular resistance (SVR) were used for the sensorless speed control algorithm and demonstrated close correlations. Based on those empirical relationships, systemic flow and SVR were calculated in the system module and showed good correlation with measured pump flow and SVR. The automatic system adjusted the pump's speed to obtain the target flow in response to the calculated SVR. Atrial pressure difference (left minus right atrial pressure) was maintained within ±10mmHg for a wide range of SVR/pulmonary vascular resistance ratios, demonstrating a wide margin of self-regulation under fixed-speed mode and 25% sinusoidally modulated speed mode. Hemolysis test results indicated acceptable values (normalized index of hemolysis <0.01mg/dL). The coupled EMAG/CFD model was validated for use in further device development.

AB - Cleveland Clinic's continuous-flow total artificial heart has one motor and one rotating assembly supported by a hydrodynamic bearing. The right hydraulic output is self regulated by passive axial movement of the rotating assembly to balance itself with the left output. The purpose of this article is to present progress in four areas of development: the automatic speed control system, self-regulation to balance right/left inlet pressures and flows, hemolysis testing using calf blood, and coupled electromagnetics (EMAG) and computational fluid dynamics (CFD) analysis. The relationships between functions of motor power and speed, systemic flow, and systemic vascular resistance (SVR) were used for the sensorless speed control algorithm and demonstrated close correlations. Based on those empirical relationships, systemic flow and SVR were calculated in the system module and showed good correlation with measured pump flow and SVR. The automatic system adjusted the pump's speed to obtain the target flow in response to the calculated SVR. Atrial pressure difference (left minus right atrial pressure) was maintained within ±10mmHg for a wide range of SVR/pulmonary vascular resistance ratios, demonstrating a wide margin of self-regulation under fixed-speed mode and 25% sinusoidally modulated speed mode. Hemolysis test results indicated acceptable values (normalized index of hemolysis <0.01mg/dL). The coupled EMAG/CFD model was validated for use in further device development.

UR - http://www.scopus.com/inward/record.url?scp=84864814887&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84864814887&partnerID=8YFLogxK

U2 - 10.1111/j.1525-1594.2012.01489.x

DO - 10.1111/j.1525-1594.2012.01489.x

M3 - Article

VL - 36

SP - 705

EP - 713

JO - Artificial Organs

JF - Artificial Organs

SN - 0160-564X

IS - 8

ER -