Progressive graft fibrosis and donor-specific human leukocyte antigen antibodies in pediatric late liver allografts

Aya Miyagawa-Hayashino, Atushi Yoshizawa, Yoichiro Uchida, Hiroto Egawa, Kimiko Yurugi, Satohiro Masuda, Sachiko Minamiguchi, Taira Maekawa, Shinji Uemoto, Hironori Haga

研究成果: ジャーナルへの寄稿記事

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The role of donor-specific anti-human leukocyte antigen antibodies (DSAs) that develop late after living donor liver transplantation is unknown. Seventy-nine pediatric recipients who had good graft function and underwent protocol liver biopsy more than 5 years after transplantation (median = 11 years, range = 5-20 years) were reviewed. DSAs were determined with the Luminex single-antigen bead assay at the time of the last biopsy, and complement component 4d (C4d) immunostaining was assessed at the times of the last biopsy and the previous biopsy. The donor specificity of antibodies could be identified in 67 patients: DSAs were detected in 32 patients (48%), and they were usually against human leukocyte antigen class II (30 cases) but were rarely against class I (2 cases). These patients had a higher frequency of bridging fibrosis or cirrhosis (28/32 or 88%) than DSA-negative patients (6/35 or 17%, P < 0.001). Fibrosis was likely to be centrilobular-based. DSA-positive patients, in comparison with DSA-negative patients, had higher frequencies of diffuse/focal endothelial C4d staining (P < 0.001) and mild/indeterminate acute rejection [15/32 (47%) versus 5/35 (14%), P = 0.004]. Four DSA-negative patients were off immunosuppression, whereas no patients in the DSA-positive group were (P = 0.048). In conclusion, the high prevalence of graft fibrosis and anti-class II DSAs in late protocol biopsy samples suggests that humoral alloreactivity may contribute to the process of unexplained graft fibrosis late after liver transplantation.

元の言語英語
ページ(範囲)1333-1342
ページ数10
ジャーナルLiver Transplantation
18
発行部数11
DOI
出版物ステータス出版済み - 11 1 2012

All Science Journal Classification (ASJC) codes

  • Surgery
  • Hepatology
  • Transplantation

フィンガープリント Progressive graft fibrosis and donor-specific human leukocyte antigen antibodies in pediatric late liver allografts' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

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    Miyagawa-Hayashino, A., Yoshizawa, A., Uchida, Y., Egawa, H., Yurugi, K., Masuda, S., Minamiguchi, S., Maekawa, T., Uemoto, S., & Haga, H. (2012). Progressive graft fibrosis and donor-specific human leukocyte antigen antibodies in pediatric late liver allografts. Liver Transplantation, 18(11), 1333-1342. https://doi.org/10.1002/lt.23534