Promotive effect of insulin-like growth factor-1 for epithelial sealing to titanium implants

研究成果: Contribution to journalArticle査読

16 被引用数 (Scopus)


Improvement of oral epithelial adhesion to titanium (Ti) may significantly enhance the efficacy of dental implants. Here, we investigated whether insulin-like growth factor-1 (IGF-1) improved the sealing of the peri-implant epithelium (PIE) around the implant. Right maxillary first molars were extracted from rats and replaced with experimental implants. After 4 weeks of IGF-1 treatment, the implant-PIE interface exhibited a band of immunoreactive laminin-332 (Ln-5), similar to the tooth-junctional epithelium interface, that was partially absent in the untreated group. Immunoelectron microscopy showed a characteristic Ln-5-positive band including hemidesmosomes at both the apical and upper portions of the implant-PIE interface in the IGF-1-treated group. We also investigated the effects of IGF-1/PI3K inhibitors on the dynamics of rat oral epithelial cells (OECs) grown on Ti plates. In OECs cultured with IGF-1, adhesion protein expression increased, cell adherence to Ti plates was higher, and proliferation was faster, whereas migration and apoptosis were induced in the absence of IGF-1 or in the presence of both IGF-1 and a PI3K inhibitor. These data suggest that PI3K mediates the promotive effects of IGF-1, and that IGF-1 is effective at enhancing epithelial integration around Ti implants. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 101A:2896-2904, 2013.

ジャーナルJournal of Biomedical Materials Research - Part A
出版ステータス出版済み - 10 2013

All Science Journal Classification (ASJC) codes

  • セラミックおよび複合材料
  • 生体材料
  • 生体医工学
  • 金属および合金


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