Propyl gallate, a strong antioxidant, increases the ca2+ sensitivity of cardiac myofilament

Naoto Tadano, Sachio Morimoto, Fumi Takahashi-Yanaga, Yoshikazu Miwa, Iwao Ohtsuki, Toshiyuki Sasaguri

研究成果: ジャーナルへの寄稿記事

7 引用 (Scopus)

抜粋

Ca2+ sensitizers are cardiotonic agents that directly increase the Ca2+ sensitivity of cardiac myofilament. To find a novel Ca2+ sensitizer, we have screened a group of phenolic compounds by examining their effects on the Ca2+-dependent force generation in cardiac muscle fibers. We found that propyl gallate, a strong antioxidant, increased the Ca2+ sensitivity of cardiac myofilament in a dose-dependent and reversible manner. The present study indicates that propyl gallate is a novel type of Ca2+ sensitizer with antioxidant activity, which might be more beneficial for the treatment of congestive heart failure associated with oxidative stress than existing Ca2+ sensitizers.

元の言語英語
ページ(範囲)456-458
ページ数3
ジャーナルJournal of Pharmacological Sciences
109
発行部数3
DOI
出版物ステータス出版済み - 6 22 2009

    フィンガープリント

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology

これを引用