Prospective study of cancer in Japanese patients with type 2 diabetes: the Fukuoka Diabetes Registry

Masanori Iwase, Hiroki Fujii, Yasuhiro Idewaki, Udai Nakamura, Toshiaki Ohkuma, Hitoshi Ide, Yuji Komorita, Tamaki Jodai-Kitamura, Masahito Yoshinari, Takanari Kitazono

研究成果: ジャーナルへの寄稿記事

抄録

Background: Although the association between type 2 diabetes and cancer has been reported, few epidemiological studies have been conducted in Japanese patients whose leading cause of death is cancer. We prospectively studied the incidence of site-specific cancer, risk factors for developing cancer, cancer death, and survival in Japanese patients with type 2 diabetes. Methods: We followed 4923 participants (mean age, 65 years) with type 2 diabetes attending an outpatient diabetes clinic for a median of 5.3 years (follow-up rate, 99.0%). Results: During the follow-up period, cancer occurred in 450 participants (incidence rate, 22.3/1000 person-years in men and 12.2/1000 person-years in women). In men, prostate cancer was the most common cancer (4.3/1000 person-years), colorectal cancer was the second (3.6/1000 person-years), and gastric cancer was the third (3.3/1000 person-years). In women, colorectal cancer was the most common cancer (2.6/1000 person-years), gastric cancer was the second (2.0/1000 person-years), and breast cancer was the third (1.4/1000 person-years). Smoking, male sex, low-density lipoprotein cholesterol, family history of cancer, and reduced intake of isoflavone daidzein were significant risk factors for developing cancer using multivariable Cox proportional hazards models. The leading cancer death was lung cancer in men and pancreatic cancer in women. The survival was the best for prostate cancer and the worst for pancreatic cancer (2-year cancer-specific survival 95.4%, 30.0%, respectively). Conclusions: Since the leading cause of death in patients with type 2 diabetes is cancer in Japan, clinicians should be aware of epidemiological data regarding cancer besides diabetic complications.

元の言語英語
ページ(範囲)260-267
ページ数8
ジャーナルDiabetology International
10
発行部数4
DOI
出版物ステータス出版済み - 10 1 2019

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Type 2 Diabetes Mellitus
Registries
Prospective Studies
Neoplasms
Pancreatic Neoplasms
Stomach Neoplasms
Survival
Cause of Death
Colorectal Neoplasms
Prostatic Neoplasms
Isoflavones
Incidence
Diabetes Complications
Ambulatory Care Facilities
Proportional Hazards Models
LDL Cholesterol
Epidemiologic Studies
Lung Neoplasms
Japan
Smoking

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

これを引用

Prospective study of cancer in Japanese patients with type 2 diabetes : the Fukuoka Diabetes Registry. / Iwase, Masanori; Fujii, Hiroki; Idewaki, Yasuhiro; Nakamura, Udai; Ohkuma, Toshiaki; Ide, Hitoshi; Komorita, Yuji; Jodai-Kitamura, Tamaki; Yoshinari, Masahito; Kitazono, Takanari.

:: Diabetology International, 巻 10, 番号 4, 01.10.2019, p. 260-267.

研究成果: ジャーナルへの寄稿記事

Iwase, M, Fujii, H, Idewaki, Y, Nakamura, U, Ohkuma, T, Ide, H, Komorita, Y, Jodai-Kitamura, T, Yoshinari, M & Kitazono, T 2019, 'Prospective study of cancer in Japanese patients with type 2 diabetes: the Fukuoka Diabetes Registry', Diabetology International, 巻. 10, 番号 4, pp. 260-267. https://doi.org/10.1007/s13340-019-00390-0
Iwase, Masanori ; Fujii, Hiroki ; Idewaki, Yasuhiro ; Nakamura, Udai ; Ohkuma, Toshiaki ; Ide, Hitoshi ; Komorita, Yuji ; Jodai-Kitamura, Tamaki ; Yoshinari, Masahito ; Kitazono, Takanari. / Prospective study of cancer in Japanese patients with type 2 diabetes : the Fukuoka Diabetes Registry. :: Diabetology International. 2019 ; 巻 10, 番号 4. pp. 260-267.
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title = "Prospective study of cancer in Japanese patients with type 2 diabetes: the Fukuoka Diabetes Registry",
abstract = "Background: Although the association between type 2 diabetes and cancer has been reported, few epidemiological studies have been conducted in Japanese patients whose leading cause of death is cancer. We prospectively studied the incidence of site-specific cancer, risk factors for developing cancer, cancer death, and survival in Japanese patients with type 2 diabetes. Methods: We followed 4923 participants (mean age, 65 years) with type 2 diabetes attending an outpatient diabetes clinic for a median of 5.3 years (follow-up rate, 99.0{\%}). Results: During the follow-up period, cancer occurred in 450 participants (incidence rate, 22.3/1000 person-years in men and 12.2/1000 person-years in women). In men, prostate cancer was the most common cancer (4.3/1000 person-years), colorectal cancer was the second (3.6/1000 person-years), and gastric cancer was the third (3.3/1000 person-years). In women, colorectal cancer was the most common cancer (2.6/1000 person-years), gastric cancer was the second (2.0/1000 person-years), and breast cancer was the third (1.4/1000 person-years). Smoking, male sex, low-density lipoprotein cholesterol, family history of cancer, and reduced intake of isoflavone daidzein were significant risk factors for developing cancer using multivariable Cox proportional hazards models. The leading cancer death was lung cancer in men and pancreatic cancer in women. The survival was the best for prostate cancer and the worst for pancreatic cancer (2-year cancer-specific survival 95.4{\%}, 30.0{\%}, respectively). Conclusions: Since the leading cause of death in patients with type 2 diabetes is cancer in Japan, clinicians should be aware of epidemiological data regarding cancer besides diabetic complications.",
author = "Masanori Iwase and Hiroki Fujii and Yasuhiro Idewaki and Udai Nakamura and Toshiaki Ohkuma and Hitoshi Ide and Yuji Komorita and Tamaki Jodai-Kitamura and Masahito Yoshinari and Takanari Kitazono",
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T1 - Prospective study of cancer in Japanese patients with type 2 diabetes

T2 - the Fukuoka Diabetes Registry

AU - Iwase, Masanori

AU - Fujii, Hiroki

AU - Idewaki, Yasuhiro

AU - Nakamura, Udai

AU - Ohkuma, Toshiaki

AU - Ide, Hitoshi

AU - Komorita, Yuji

AU - Jodai-Kitamura, Tamaki

AU - Yoshinari, Masahito

AU - Kitazono, Takanari

PY - 2019/10/1

Y1 - 2019/10/1

N2 - Background: Although the association between type 2 diabetes and cancer has been reported, few epidemiological studies have been conducted in Japanese patients whose leading cause of death is cancer. We prospectively studied the incidence of site-specific cancer, risk factors for developing cancer, cancer death, and survival in Japanese patients with type 2 diabetes. Methods: We followed 4923 participants (mean age, 65 years) with type 2 diabetes attending an outpatient diabetes clinic for a median of 5.3 years (follow-up rate, 99.0%). Results: During the follow-up period, cancer occurred in 450 participants (incidence rate, 22.3/1000 person-years in men and 12.2/1000 person-years in women). In men, prostate cancer was the most common cancer (4.3/1000 person-years), colorectal cancer was the second (3.6/1000 person-years), and gastric cancer was the third (3.3/1000 person-years). In women, colorectal cancer was the most common cancer (2.6/1000 person-years), gastric cancer was the second (2.0/1000 person-years), and breast cancer was the third (1.4/1000 person-years). Smoking, male sex, low-density lipoprotein cholesterol, family history of cancer, and reduced intake of isoflavone daidzein were significant risk factors for developing cancer using multivariable Cox proportional hazards models. The leading cancer death was lung cancer in men and pancreatic cancer in women. The survival was the best for prostate cancer and the worst for pancreatic cancer (2-year cancer-specific survival 95.4%, 30.0%, respectively). Conclusions: Since the leading cause of death in patients with type 2 diabetes is cancer in Japan, clinicians should be aware of epidemiological data regarding cancer besides diabetic complications.

AB - Background: Although the association between type 2 diabetes and cancer has been reported, few epidemiological studies have been conducted in Japanese patients whose leading cause of death is cancer. We prospectively studied the incidence of site-specific cancer, risk factors for developing cancer, cancer death, and survival in Japanese patients with type 2 diabetes. Methods: We followed 4923 participants (mean age, 65 years) with type 2 diabetes attending an outpatient diabetes clinic for a median of 5.3 years (follow-up rate, 99.0%). Results: During the follow-up period, cancer occurred in 450 participants (incidence rate, 22.3/1000 person-years in men and 12.2/1000 person-years in women). In men, prostate cancer was the most common cancer (4.3/1000 person-years), colorectal cancer was the second (3.6/1000 person-years), and gastric cancer was the third (3.3/1000 person-years). In women, colorectal cancer was the most common cancer (2.6/1000 person-years), gastric cancer was the second (2.0/1000 person-years), and breast cancer was the third (1.4/1000 person-years). Smoking, male sex, low-density lipoprotein cholesterol, family history of cancer, and reduced intake of isoflavone daidzein were significant risk factors for developing cancer using multivariable Cox proportional hazards models. The leading cancer death was lung cancer in men and pancreatic cancer in women. The survival was the best for prostate cancer and the worst for pancreatic cancer (2-year cancer-specific survival 95.4%, 30.0%, respectively). Conclusions: Since the leading cause of death in patients with type 2 diabetes is cancer in Japan, clinicians should be aware of epidemiological data regarding cancer besides diabetic complications.

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DO - 10.1007/s13340-019-00390-0

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VL - 10

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JO - Diabetology International

JF - Diabetology International

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