Protection against methotrexate toxicity by a soybean protein- and ω-3 fatty acid-containing diet

Comparative study with a casein-containing diet

Kenji Mitsugi, Tsuyoshi Nakamura, Norio Kashiwabara, hiroshi ariyama, Risa Tanaka, Eishi Baba, Minoru Nakamura, Mine Harada, Shuji Nakano

研究成果: ジャーナルへの寄稿記事

11 引用 (Scopus)

抄録

Effects of two clinically used liquid diets on toxicity and antitumor activity of methotrexate (MTX) were investigated in Sprague-Dawley (SD) rats and tumor-bearing mice, respectively. Diets tested were commercially available formulas enriched either with soybean and omega-3 fatty acids or with casein. The soybean-containing diet offered significant protection against MTX toxicity in rats compared with the casein-containing diet, completely alleviating MTX-induced anorexia, diarrhea, and weight loss, when ingested as the sole diet and fed 7 days prior to and 7 days following intraperitoneal MTX injection. As a result, 90% of rats were alive on soybean-containing diet while all rats were dead on casein-containing diet. Histologic examination of the small intestine of MTX-treated rats revealed that the soybean-containing diet significantly prevented loss of mucosal villus tips compared to the casein-containing diet. Pharmocokinetic examination indicated that plasma MTX concentrations were similar for rats in the two diet-defined groups. No significant differences were observed between diets in survival of mice injected with L1210 mouse leukemia cells and subsequently with MTX. Thus the soybean-containing diet appeared to be superior to the casein-containing diet in preventing gastrointestinal toxicity while preserving antitumor activity. A soybean diet enriched in ω-3 fatty acids may be a useful adjunct to MTX treatment of human cancers.

元の言語英語
ページ(範囲)41-45
ページ数5
ジャーナルOncology reports
12
発行部数1
出版物ステータス出版済み - 7 1 2004

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Soybean Proteins
Caseins
Methotrexate
Fatty Acids
Diet
Soybeans
Leukemia L1210
Omega-3 Fatty Acids
Anorexia
Intraperitoneal Injections
Small Intestine
Sprague Dawley Rats
Weight Loss

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

これを引用

Protection against methotrexate toxicity by a soybean protein- and ω-3 fatty acid-containing diet : Comparative study with a casein-containing diet. / Mitsugi, Kenji; Nakamura, Tsuyoshi; Kashiwabara, Norio; ariyama, hiroshi; Tanaka, Risa; Baba, Eishi; Nakamura, Minoru; Harada, Mine; Nakano, Shuji.

:: Oncology reports, 巻 12, 番号 1, 01.07.2004, p. 41-45.

研究成果: ジャーナルへの寄稿記事

Mitsugi, K, Nakamura, T, Kashiwabara, N, ariyama, H, Tanaka, R, Baba, E, Nakamura, M, Harada, M & Nakano, S 2004, 'Protection against methotrexate toxicity by a soybean protein- and ω-3 fatty acid-containing diet: Comparative study with a casein-containing diet', Oncology reports, 巻. 12, 番号 1, pp. 41-45.
Mitsugi, Kenji ; Nakamura, Tsuyoshi ; Kashiwabara, Norio ; ariyama, hiroshi ; Tanaka, Risa ; Baba, Eishi ; Nakamura, Minoru ; Harada, Mine ; Nakano, Shuji. / Protection against methotrexate toxicity by a soybean protein- and ω-3 fatty acid-containing diet : Comparative study with a casein-containing diet. :: Oncology reports. 2004 ; 巻 12, 番号 1. pp. 41-45.
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