Protection mechanisms against aberrant metabolism of sphingolipids in budding yeast

Motohiro Tani, Kouichi Funato

研究成果: ジャーナルへの寄稿評論記事

5 引用 (Scopus)

抄録

Life is dependent on the protection of cellular functions from various stresses. Sphingolipids are essential biomembrane components in eukaryotic organisms, which are exposed to risks that may disrupt sphingolipid metabolism, threatening their lives. Defects of the sphingolipid biosynthesis pathway cause profound defects of various cellular functions and ultimately cell death. Therefore, cells are equipped with defense response mechanisms against aberrant metabolism of sphingolipids, the most characterized one being the target of rapamycin complex 2-mediated regulation of sphingolipid biosynthesis in budding yeast Saccharomyces cerevisiae. On the other hand, very recently, we found that the high osmolarity glycerol pathway is involved in suppression of a growth defect caused by a reduction in complex sphingolipid levels in yeast. It is suggested that this signaling pathway is not involved in the repair of the impaired biosynthesis pathway for sphingolipids, but compensates for cellular dysfunctions caused by reduction in complex sphingolipid levels. This is a novel protection mechanism against aberrant metabolism of complex sphingolipids, and further investigation of the mechanism will provide new insights into the physiological significance of complex sphingolipids. Here, we summarize the response signaling against breakdown of sphingolipid biosynthesis in yeast, which includes the high osmolarity glycerol pathway.

元の言語英語
ページ(範囲)1021-1028
ページ数8
ジャーナルCurrent Genetics
64
発行部数5
DOI
出版物ステータス出版済み - 10 1 2018

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Sphingolipids
Saccharomycetales
Osmolar Concentration
Glycerol
Yeasts
Saccharomyces cerevisiae
Cell Death

All Science Journal Classification (ASJC) codes

  • Genetics

これを引用

Protection mechanisms against aberrant metabolism of sphingolipids in budding yeast. / Tani, Motohiro; Funato, Kouichi.

:: Current Genetics, 巻 64, 番号 5, 01.10.2018, p. 1021-1028.

研究成果: ジャーナルへの寄稿評論記事

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