Protective effect of Lactobacillus casei on Pseudomonas aeruginosa infection in mice

S. Miake, K. Nomoto, T. Yokokura, Yasunobu Yoshikai, M. Mutai

    研究成果: ジャーナルへの寄稿記事

    50 引用 (Scopus)

    抄録

    The protective effect of heat-killed Lactobacillus casei YIT9018 (LC 9018) against Pseudomonas aeruginosa infection in mice was compared with that of Corynebacterium parvum. Survival of mice after intraperitoneal (i.p.) infection with P. aeruginosa was augmented in mice that had been pretreated i.p. with LC 9018 5 days previously. Similar treatment of mice with C. parvum, however, was not effective at all. Moreover, mice became more susceptible to infection with P. aeruginosa after such treatment. Growth of P. aeruginosa in the peritoneal cavity and spleen was markedly inhibited in LC 9018-pretreated mice, whereas such inhibition of bacterial growth was not observed in C. parvum-treated mice. The protective effect of LC 9018 was observed in mice subjected to 800 rads of whole body irradiation but was abrogated when mice were treated with carrageenan. These results suggest that augmentation of the resistance of mice to P. aeruginosa was caused by the induction of activated macrophages. The number of macrophages detectable in the peritoneal cavity was almost the same in LC 9018- and C. parvum-treated mice. Growth of Listeria monocytogenes was inhibited by pretreatment with LC 9018. Inhibition of L. monocytogenes was also observed after the same pretreatment with C. parvum. It was suggested that macrophages activated with LC 9018 were involved in the protective immunity to P. aeruginosa.

    元の言語英語
    ページ(範囲)480-485
    ページ数6
    ジャーナルInfection and Immunity
    48
    発行部数2
    出版物ステータス出版済み - 8 14 1985

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    Lactobacillus casei
    Pseudomonas Infections
    Pseudomonas aeruginosa
    Propionibacterium acnes
    Macrophages
    Peritoneal Cavity
    Listeria monocytogenes
    Growth
    Whole-Body Irradiation
    Carrageenan
    Infection
    Immunity
    Spleen
    Hot Temperature

    All Science Journal Classification (ASJC) codes

    • Parasitology
    • Microbiology
    • Immunology
    • Infectious Diseases

    これを引用

    Miake, S., Nomoto, K., Yokokura, T., Yoshikai, Y., & Mutai, M. (1985). Protective effect of Lactobacillus casei on Pseudomonas aeruginosa infection in mice. Infection and Immunity, 48(2), 480-485.

    Protective effect of Lactobacillus casei on Pseudomonas aeruginosa infection in mice. / Miake, S.; Nomoto, K.; Yokokura, T.; Yoshikai, Yasunobu; Mutai, M.

    :: Infection and Immunity, 巻 48, 番号 2, 14.08.1985, p. 480-485.

    研究成果: ジャーナルへの寄稿記事

    Miake, S, Nomoto, K, Yokokura, T, Yoshikai, Y & Mutai, M 1985, 'Protective effect of Lactobacillus casei on Pseudomonas aeruginosa infection in mice', Infection and Immunity, 巻. 48, 番号 2, pp. 480-485.
    Miake S, Nomoto K, Yokokura T, Yoshikai Y, Mutai M. Protective effect of Lactobacillus casei on Pseudomonas aeruginosa infection in mice. Infection and Immunity. 1985 8 14;48(2):480-485.
    Miake, S. ; Nomoto, K. ; Yokokura, T. ; Yoshikai, Yasunobu ; Mutai, M. / Protective effect of Lactobacillus casei on Pseudomonas aeruginosa infection in mice. :: Infection and Immunity. 1985 ; 巻 48, 番号 2. pp. 480-485.
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    abstract = "The protective effect of heat-killed Lactobacillus casei YIT9018 (LC 9018) against Pseudomonas aeruginosa infection in mice was compared with that of Corynebacterium parvum. Survival of mice after intraperitoneal (i.p.) infection with P. aeruginosa was augmented in mice that had been pretreated i.p. with LC 9018 5 days previously. Similar treatment of mice with C. parvum, however, was not effective at all. Moreover, mice became more susceptible to infection with P. aeruginosa after such treatment. Growth of P. aeruginosa in the peritoneal cavity and spleen was markedly inhibited in LC 9018-pretreated mice, whereas such inhibition of bacterial growth was not observed in C. parvum-treated mice. The protective effect of LC 9018 was observed in mice subjected to 800 rads of whole body irradiation but was abrogated when mice were treated with carrageenan. These results suggest that augmentation of the resistance of mice to P. aeruginosa was caused by the induction of activated macrophages. The number of macrophages detectable in the peritoneal cavity was almost the same in LC 9018- and C. parvum-treated mice. Growth of Listeria monocytogenes was inhibited by pretreatment with LC 9018. Inhibition of L. monocytogenes was also observed after the same pretreatment with C. parvum. It was suggested that macrophages activated with LC 9018 were involved in the protective immunity to P. aeruginosa.",
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