Protective effect of nitric oxide on development of acute pancreatitis in rats

Xiaohong Liu, Itsuro Nakano, Hiroya Yamaguchi, Tetsuhide Ito, Masayoshi Goto, Shujiro Koyanagi, Mitsuru Kinjoh, Hajime Nawata

研究成果: Contribution to journalArticle査読

64 被引用数 (Scopus)

抄録

Nitric oxide (NO) has been implicated to regulate pancreatic circulation, promote capillary integrity, and inhibit leukocyte adhesion. We investigated the role of NO in the development of pancreatitis. Nitro-l-arginine, an inhibitor of NO synthase, in total dose of 35 mg/kg body wt was infused in the rats with edematous pancreatitis induced by two intraperitoneal injections of cerulein (20 μg/kg). l-Arginine (125 or 250 mg/kg), a NO donor was intravenously administered twice in the rats with hemorrhagic pancreatitis induced by waterimmersion stress plus two intraperitoneal injections of cerulein (40 μg/kg). The degree of pancreas edema, serum amylase levels, and histologic alterations were investigated. Nitro-l-arginine exacerbated cerulein-induced pancreatitis and caused a decrease in pancreatic blood flow. l-Arginine ameliorated the severity of hemorrhagic pancreatitis dose dependently and improved the pancreatic blood flow. These findings suggest that NO could confer protection against the development of hemorrhagic pancreatitis, probably through improvement of the pancreatic microcirculation.

本文言語英語
ページ(範囲)2162-2169
ページ数8
ジャーナルDigestive Diseases and Sciences
40
10
DOI
出版ステータス出版済み - 10 1 1995

All Science Journal Classification (ASJC) codes

  • 生理学
  • 消化器病学

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