Protective role of peroxisome proliferator-activated receptor α agonists in skin barrier and inflammation

Kazuhisa Furue, Chikage Mitoma, Gaku Tsuji, Masutaka Furue

研究成果: ジャーナルへの寄稿評論記事

5 引用 (Scopus)

抄録

Peroxisome proliferator-activated receptor α (PPARα) is one of the three isoforms of PPARs, which are ligand-activated nuclear transcription factors. PPARα is highly expressed in liver and its agonists are widely used to treat hyperlipidemia. Epidermal keratinocytes express all three isoforms (α, β/δ, and γ) of PPARs and PPARα is particularly important for regulating the epidermal barrier and inflammation. Agonistic ligation of PPARα protects the epidermal barrier function and inhibits the inflammatory response in dermatitis. In this review, we summarize recent topics on the role of PPARα in skin biology and discuss the potential use of topical PPARα agonists for treating atopic dermatitis and other eczemas.

元の言語英語
ページ(範囲)327-330
ページ数4
ジャーナルImmunobiology
223
発行部数3
DOI
出版物ステータス出版済み - 3 1 2018

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Peroxisome Proliferator-Activated Receptors
Inflammation
Skin
Protein Isoforms
Eczema
Dermatitis
Atopic Dermatitis
Hyperlipidemias
Keratinocytes
Ligation
Transcription Factors
Ligands
Liver

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Hematology

これを引用

Protective role of peroxisome proliferator-activated receptor α agonists in skin barrier and inflammation. / Furue, Kazuhisa; Mitoma, Chikage; Tsuji, Gaku; Furue, Masutaka.

:: Immunobiology, 巻 223, 番号 3, 01.03.2018, p. 327-330.

研究成果: ジャーナルへの寄稿評論記事

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