Protective role of peroxisome proliferator-activated receptor α agonists in skin barrier and inflammation

Kazuhisa Furue; Chikage Mitoma; Gaku Tsuji; Masutaka Furue

doi:10.1016/j.imbio.2017.10.047

Protective role of peroxisome proliferator-activated receptor α agonists in skin barrier and inflammation

Kazuhisa Furue, Chikage Mitoma, Gaku Tsuji, Masutaka Furue

研究成果: ジャーナルへの寄稿 › 総説 › 査読

14 被引用数 (Scopus)

抄録

Peroxisome proliferator-activated receptor α (PPARα) is one of the three isoforms of PPARs, which are ligand-activated nuclear transcription factors. PPARα is highly expressed in liver and its agonists are widely used to treat hyperlipidemia. Epidermal keratinocytes express all three isoforms (α, β/δ, and γ) of PPARs and PPARα is particularly important for regulating the epidermal barrier and inflammation. Agonistic ligation of PPARα protects the epidermal barrier function and inhibits the inflammatory response in dermatitis. In this review, we summarize recent topics on the role of PPARα in skin biology and discuss the potential use of topical PPARα agonists for treating atopic dermatitis and other eczemas.

本文言語	英語
ページ（範囲）	327-330
ページ数	4
ジャーナル	Immunobiology
巻	223
号	3
DOI	https://doi.org/10.1016/j.imbio.2017.10.047
出版ステータス	出版済み - 3月 2018

!!!All Science Journal Classification (ASJC) codes

免疫アレルギー学
免疫学
血液学

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10.1016/j.imbio.2017.10.047

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title = "Protective role of peroxisome proliferator-activated receptor α agonists in skin barrier and inflammation",

abstract = "Peroxisome proliferator-activated receptor α (PPARα) is one of the three isoforms of PPARs, which are ligand-activated nuclear transcription factors. PPARα is highly expressed in liver and its agonists are widely used to treat hyperlipidemia. Epidermal keratinocytes express all three isoforms (α, β/δ, and γ) of PPARs and PPARα is particularly important for regulating the epidermal barrier and inflammation. Agonistic ligation of PPARα protects the epidermal barrier function and inhibits the inflammatory response in dermatitis. In this review, we summarize recent topics on the role of PPARα in skin biology and discuss the potential use of topical PPARα agonists for treating atopic dermatitis and other eczemas.",

author = "Kazuhisa Furue and Chikage Mitoma and Gaku Tsuji and Masutaka Furue",

note = "Funding Information: This work was partly supported by a grant ( H27-Shokuhin-Shitei-017 ) for Research on Food Safety from The Ministry of Health, Labour and Welfare, Japan . Publisher Copyright: {\textcopyright} 2017 Elsevier GmbH",

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AU - Furue, Kazuhisa

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AU - Tsuji, Gaku

AU - Furue, Masutaka

N1 - Funding Information: This work was partly supported by a grant ( H27-Shokuhin-Shitei-017 ) for Research on Food Safety from The Ministry of Health, Labour and Welfare, Japan . Publisher Copyright: © 2017 Elsevier GmbH

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Protective role of peroxisome proliferator-activated receptor α agonists in skin barrier and inflammation

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!!!All Science Journal Classification (ASJC) codes

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