Protective roles of T cells and interleukin-15 in Escherichia coli infection in mice

M. Takano, H. Nishimura, Y. Kimura, Y. Mokuno, J. Washizu, S. Itohara, Y. Nimura, Y. Yoshikai

    研究成果: ジャーナルへの寄稿記事

    65 引用 (Scopus)

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    The number of γδ T cells in the peritoneal cavity was increased after an intraperitoneal (i.p.) infection with Escherichia coil in lipopolysaccharide (LPS)-responsive C3H/HeN mice but not in LPS- hyporesponsive C3H/HeJ mice. The γδ T cells preferentially expressed invariant Vγ6 and Vδ1 chains and proliferated to produce a large amount of gamma interferon in the presence of LPS. Mice depleted of γδ T cells by T- cell receptor δ gene mutation showed impaired resistance against E. coil as assessed by bacterial growth. Macrophages from C3H/HeN mice infected with E. coli expressed higher levels of interleukin-15 (IL-15) mRNA than those from the infected C3H/HeJ mice. Administration of anti-IL-15 monoclonal antibody inhibited, albeit partially, the appearance of γδ T cells in C3H/HeN mice after E. coli infection and diminished the host defense against the infection. These results suggest that LPS-stimulated γδ T cells play an important role in the host defense against E. coil infection and that IL-15 may be partly involved in the protection via an increase in the γδ T cells.

    元の言語英語
    ページ(範囲)3270-3278
    ページ数9
    ジャーナルInfection and Immunity
    66
    発行部数7
    出版物ステータス出版済み - 7 1 1998

      フィンガープリント

    All Science Journal Classification (ASJC) codes

    • Parasitology
    • Microbiology
    • Immunology
    • Infectious Diseases

    これを引用

    Takano, M., Nishimura, H., Kimura, Y., Mokuno, Y., Washizu, J., Itohara, S., ... Yoshikai, Y. (1998). Protective roles of T cells and interleukin-15 in Escherichia coli infection in mice. Infection and Immunity, 66(7), 3270-3278.