Protein-bound polysaccharide-K reduces colitic tumors and improves survival of inflammatory bowel disease in vivo

Norifumi Tsutsumi, Shunji Kohnoe, Hideto Sonoda, Atsushi Guntani, Tatsuya Rikimaru, Ken Ichi Taguchi, Morimasa Tomikawa, Yoshihiro Kakeji, Hideaki Nakashima, Yoshihiko Maehara

研究成果: Contribution to journalArticle査読

2 被引用数 (Scopus)

抄録

Protein-bound polysaccharide-K (PSK) is a biological response modifier that possesses antitumor effects against various tumors. Although an inflammatory response has been considered to play an important role in the development of colorectal cancer, the anti-inflammatory effect of PSK has yet to be elucidated. An inflammatory bowel disease (IBD)-induced colorectal tumor model with 1.2-dimethyl hydrazine (DMH) and dextran sodium sulfate (DSS) was used to examine the effects of PSK on tumor suppression and survival. Although 90% of the mice that were not treated with PSK developed colitic tumors, oral administration of PSK suppressed tumor formation by less than 30%. Although deaths associated with DSS-induced melena were observed, PSK significantly reduced mortality. In conclusion, the present study showed that PSK not only suppressed colorectal tumor formation in the DMH+DSS-induced IBD model, but also improved the survival rate, indicating that anti-inflammatory activity is one of the mechanisms for the antitumor effects of PSK.

本文言語英語
ページ(範囲)791-796
ページ数6
ジャーナルOncology Letters
2
5
DOI
出版ステータス出版済み - 9 2011

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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