Proteolytic cascades and their involvement in invertebrate immunity

Lage Cerenius, Shun-Ichiro Kawabata, Bok Luel Lee, Masaru Nonaka, Kenneth Söderhäll

研究成果: Contribution to journalReview article査読

223 被引用数 (Scopus)


Bacteria and other potential pathogens are cleared rapidly from the body fluids of invertebrates by the immediate response of the innate immune system. Proteolytic cascades, following their initiation by pattern recognition proteins, control several such reactions, notably coagulation, melanisation, activation of the Toll receptor and complement-like reactions. However, there is considerable variation among invertebrates and these cascades, although widespread, are not present in all phyla. In recent years, significant progress has been made in identifying and characterizing these cascades in insects. Notably, recent work has identified several connections and shared principles among the different pathways, suggesting that cross-talk between them may be common.

ジャーナルTrends in Biochemical Sciences
出版ステータス出版済み - 10 1 2010

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology

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