TY - JOUR
T1 - Proteomic study of retinal proteins associated with transcorneal electric stimulation in rats
AU - Kanamoto, Takashi
AU - Souchelnytskyi, Nazariy
AU - Kurimoto, Takuji
AU - Ikeda, Yasuhiro
AU - Sakaue, Hiroaki
AU - Munemasa, Yasunari
AU - Kiuchi, Yoshiaki
N1 - Publisher Copyright:
© 2015 Takashi Kanamoto et al.
Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.
PY - 2015
Y1 - 2015
N2 - Background. To investigate how transcorneal electric stimulation (TES) affects the retina, by identifying those proteins up-and downregulated by transcorneal electric stimulation (TES) in the retina of rats. Methods. Adult Wistar rats received TES on the left eyes at different electrical currents while the right eyes received no treatment and served as controls. After TES, the eye was enucleated and the retina was isolated. The retinas were analyzed by proteomics. Results. Proteomics showed that twenty-five proteins were upregulated by TES. The identified proteins included cellular signaling proteins, proteins associated with neuronal transmission, metabolic proteins, immunological factors, and structural proteins. Conclusions. TES induced changes in expression of various functional proteins in the retina.
AB - Background. To investigate how transcorneal electric stimulation (TES) affects the retina, by identifying those proteins up-and downregulated by transcorneal electric stimulation (TES) in the retina of rats. Methods. Adult Wistar rats received TES on the left eyes at different electrical currents while the right eyes received no treatment and served as controls. After TES, the eye was enucleated and the retina was isolated. The retinas were analyzed by proteomics. Results. Proteomics showed that twenty-five proteins were upregulated by TES. The identified proteins included cellular signaling proteins, proteins associated with neuronal transmission, metabolic proteins, immunological factors, and structural proteins. Conclusions. TES induced changes in expression of various functional proteins in the retina.
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U2 - 10.1155/2015/492050
DO - 10.1155/2015/492050
M3 - Article
AN - SCOPUS:84925433209
VL - 2015
JO - Journal of Ophthalmology
JF - Journal of Ophthalmology
SN - 2090-004X
M1 - 492050
ER -