Protracted administration of L-asparaginase in maintenance phase is the risk factor for hyperglycemia in older patients with pediatric acute lymphoblastic leukemia

Hideki Yoshida, Toshihiko Imamura, Akiko M. Saito, Yoshihiro Takahashi, Soichi Suenobu, Daiichiro Hasegawa, Takao Deguchi, Yoshiko Hashii, Hirohide Kawasaki, Mikiya Endo, Hiroki Hori, Nobuhiro Suzuki, Yoshiyuki Kosaka, Koji Kato, Keiko Yumura-Yagi, Junichi Hara, Megumi Oda, Atsushi Sato, Keizo Horibe

    研究成果: ジャーナルへの寄稿記事

    7 引用 (Scopus)

    抄録

    Although L-asparaginase related hyperglycemia is well known adverse event, it is not studied whether the profile of this adverse event is affected by intensification of L-asparaginase administration. Here, we analyzed the profile of L-asparaginase related hyperglycemia in a 1,176 patients with pediatric acute lymphoblastic leukemia treated according to the Japan Association of Childhood Leukemia Study ALL-02 protocol using protracted L-asparaginase administration in maintenance phase. We determined that a total of 75 L-asparaginase related hyperglycemia events occurred in 69 patients. Although 17 events (17/1176,1.4%) developed in induction phase, which was lower incidence than those (10-15%) in previous reports, 45 events developed during the maintenance phase with protracted L-asparaginase administration. Multivariate analysis showed that older age at onset (≥ 10 years) was a sole independent risk factor for L-asparaginase-related hyperglycemia (P<0.01), especially in maintenance phase. Contrary to the previous reports, obesity was not associated with L-asparaginase-related hyperglycemia. These findings suggest that protracted administration of L-asparaginase is the risk factor for hyperglycemia when treating adolescent and young adult acute lymphoblastic leukemia patients.

    元の言語英語
    記事番号e0136428
    ジャーナルPloS one
    10
    発行部数8
    DOI
    出版物ステータス出版済み - 8 28 2015

    Fingerprint

    asparaginase
    Asparaginase
    lymphocytic leukemia
    Pediatrics
    hyperglycemia
    Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Hyperglycemia
    risk factors
    Maintenance
    leukemia
    young adults
    Age of Onset
    childhood
    multivariate analysis
    Young Adult
    Japan
    Leukemia
    obesity
    Multivariate Analysis
    Obesity

    All Science Journal Classification (ASJC) codes

    • Biochemistry, Genetics and Molecular Biology(all)
    • Agricultural and Biological Sciences(all)
    • General

    これを引用

    Protracted administration of L-asparaginase in maintenance phase is the risk factor for hyperglycemia in older patients with pediatric acute lymphoblastic leukemia. / Yoshida, Hideki; Imamura, Toshihiko; Saito, Akiko M.; Takahashi, Yoshihiro; Suenobu, Soichi; Hasegawa, Daiichiro; Deguchi, Takao; Hashii, Yoshiko; Kawasaki, Hirohide; Endo, Mikiya; Hori, Hiroki; Suzuki, Nobuhiro; Kosaka, Yoshiyuki; Kato, Koji; Yumura-Yagi, Keiko; Hara, Junichi; Oda, Megumi; Sato, Atsushi; Horibe, Keizo.

    :: PloS one, 巻 10, 番号 8, e0136428, 28.08.2015.

    研究成果: ジャーナルへの寄稿記事

    Yoshida, H, Imamura, T, Saito, AM, Takahashi, Y, Suenobu, S, Hasegawa, D, Deguchi, T, Hashii, Y, Kawasaki, H, Endo, M, Hori, H, Suzuki, N, Kosaka, Y, Kato, K, Yumura-Yagi, K, Hara, J, Oda, M, Sato, A & Horibe, K 2015, 'Protracted administration of L-asparaginase in maintenance phase is the risk factor for hyperglycemia in older patients with pediatric acute lymphoblastic leukemia', PloS one, 巻. 10, 番号 8, e0136428. https://doi.org/10.1371/journal.pone.0136428
    Yoshida, Hideki ; Imamura, Toshihiko ; Saito, Akiko M. ; Takahashi, Yoshihiro ; Suenobu, Soichi ; Hasegawa, Daiichiro ; Deguchi, Takao ; Hashii, Yoshiko ; Kawasaki, Hirohide ; Endo, Mikiya ; Hori, Hiroki ; Suzuki, Nobuhiro ; Kosaka, Yoshiyuki ; Kato, Koji ; Yumura-Yagi, Keiko ; Hara, Junichi ; Oda, Megumi ; Sato, Atsushi ; Horibe, Keizo. / Protracted administration of L-asparaginase in maintenance phase is the risk factor for hyperglycemia in older patients with pediatric acute lymphoblastic leukemia. :: PloS one. 2015 ; 巻 10, 番号 8.
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    abstract = "Although L-asparaginase related hyperglycemia is well known adverse event, it is not studied whether the profile of this adverse event is affected by intensification of L-asparaginase administration. Here, we analyzed the profile of L-asparaginase related hyperglycemia in a 1,176 patients with pediatric acute lymphoblastic leukemia treated according to the Japan Association of Childhood Leukemia Study ALL-02 protocol using protracted L-asparaginase administration in maintenance phase. We determined that a total of 75 L-asparaginase related hyperglycemia events occurred in 69 patients. Although 17 events (17/1176,1.4{\%}) developed in induction phase, which was lower incidence than those (10-15{\%}) in previous reports, 45 events developed during the maintenance phase with protracted L-asparaginase administration. Multivariate analysis showed that older age at onset (≥ 10 years) was a sole independent risk factor for L-asparaginase-related hyperglycemia (P<0.01), especially in maintenance phase. Contrary to the previous reports, obesity was not associated with L-asparaginase-related hyperglycemia. These findings suggest that protracted administration of L-asparaginase is the risk factor for hyperglycemia when treating adolescent and young adult acute lymphoblastic leukemia patients.",
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    AU - Yoshida, Hideki

    AU - Imamura, Toshihiko

    AU - Saito, Akiko M.

    AU - Takahashi, Yoshihiro

    AU - Suenobu, Soichi

    AU - Hasegawa, Daiichiro

    AU - Deguchi, Takao

    AU - Hashii, Yoshiko

    AU - Kawasaki, Hirohide

    AU - Endo, Mikiya

    AU - Hori, Hiroki

    AU - Suzuki, Nobuhiro

    AU - Kosaka, Yoshiyuki

    AU - Kato, Koji

    AU - Yumura-Yagi, Keiko

    AU - Hara, Junichi

    AU - Oda, Megumi

    AU - Sato, Atsushi

    AU - Horibe, Keizo

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    N2 - Although L-asparaginase related hyperglycemia is well known adverse event, it is not studied whether the profile of this adverse event is affected by intensification of L-asparaginase administration. Here, we analyzed the profile of L-asparaginase related hyperglycemia in a 1,176 patients with pediatric acute lymphoblastic leukemia treated according to the Japan Association of Childhood Leukemia Study ALL-02 protocol using protracted L-asparaginase administration in maintenance phase. We determined that a total of 75 L-asparaginase related hyperglycemia events occurred in 69 patients. Although 17 events (17/1176,1.4%) developed in induction phase, which was lower incidence than those (10-15%) in previous reports, 45 events developed during the maintenance phase with protracted L-asparaginase administration. Multivariate analysis showed that older age at onset (≥ 10 years) was a sole independent risk factor for L-asparaginase-related hyperglycemia (P<0.01), especially in maintenance phase. Contrary to the previous reports, obesity was not associated with L-asparaginase-related hyperglycemia. These findings suggest that protracted administration of L-asparaginase is the risk factor for hyperglycemia when treating adolescent and young adult acute lymphoblastic leukemia patients.

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