Protrudin induces neurite formation by directional membrane trafficking

Michiko Shirane, Keiichi I. Nakayama

研究成果: ジャーナルへの寄稿記事

128 引用 (Scopus)

抜粋

Guanosine triphosphatases of the Rab family are key regulators of membrane trafficking, with Rab11 playing a specific role in membrane recycling. We identified a mammalian protein, protrudin, that promoted neurite formation through interaction with the guanosine diphosphate (GDP)-bound form of Rab11. Phosphprylation of protrudin by extracellular signal-regulated kinase (ERK) in response to nerve growth factor promoted protrudin association with Rab11-GDP. Down-regulation of protrudin by RNA interference induced membrane extension in all directions and inhibited neurite formation. Thus, protrudin regulates Rab11-dependent membrane recycling to promote the directional membrane trafficking required for neurite formation.

元の言語英語
ページ(範囲)818-821
ページ数4
ジャーナルScience
314
発行部数5800
DOI
出版物ステータス出版済み - 11 3 2006

All Science Journal Classification (ASJC) codes

  • General

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