Psychological stress impairs hepatic blood flow via central CRF receptors in mice

Yoichi Chida, Nobuyuki Sudo, Chiharu Kubo

研究成果: ジャーナルへの寄稿学術誌査読

15 被引用数 (Scopus)

抄録

Some previous works have further expanded the 'Brain-Gut axis', that is a bi-directional interaction between the gut and brain function, into a relationship of the brain with the liver. However, all the details of such brain-liver relationship were not fully understood because appropriate animal models had not been established yet. Here we developed a novel animal model, in which hepatic blood flow of conscious mice could be measured in real-time. In addition, using this model, we also demonstrated that exposure to psychological stress considerably reduced hepatic blood flow via central CRF receptors. Thus, this new model is considered to be a useful and promising tool for elucidating the precise effects of emotional factors on liver function.

本文言語英語
ページ(範囲)1707-1712
ページ数6
ジャーナルLife Sciences
76
15
DOI
出版ステータス出版済み - 2月 25 2005
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 生化学、遺伝学、分子生物学(全般)
  • 薬理学、毒性学および薬学(全般)

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